Novel Exocyclic Nucleoside Related to Clitocine: A Convergent Synthesis of 3′-Azido-2′,3′-dideoxy Clitocine

被引：6

作者：

Guo, Xianghai ^{[1
,2
]}

Liu, Can ^{[3
]}

Zheng, Lanxi ^{[3
]}

Jiang, Shende ^{[3
]}

Shen, Jiaxiang ^{[3
]}

机构：

[1] Tianjin Univ, Minist Educ, Key Lab Syst Bioengn, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Dept Pharmaceut Engn, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

[3] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

来源：

SYNLETT | 2010年 / 13期

关键词：

nucleoside analogues; exocyclic nucleosides; convergent synthesis; clitocine; antiviral drug; POTENTIAL ANTIVIRAL DRUGS; INSECTICIDAL NUCLEOSIDE; CARBOCYCLIC CLITOCINE; AMINO NUCLEOSIDE; ADENOSINE KINASE; ANALOGS; INVERSA; OLIGONUCLEOTIDE; INHIBITORS; CELLS;

D O I：

10.1055/s-0030-1258503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new clitocine derivative was achieved through a convergent strategy. A protected 4,6-diamino-5-nitropyrimidine was condensed with p-chlorobenzoyl (PCB)-protected methyl 3'-azido-2',3'-dideoxyribofuranoside, followed by subsequently deprotection to give the desired product.

引用

页码：1959 / 1962

页数：4

共 50 条

[41] Synthesis of the 2,3,4-triacetyl-1,6-dideoxy-L-mannose and tetracetyl-3,6-dideoxy-L-mannitol and the study of the reaction mechanism by molecular modeling
Banuelos-Hernandez, A. E.
Mendoza-Espinoza, J. A.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2014, 84 (07) : 1450 - 1457
[42] Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted-1,2,4-Oxadiazoles
Reddy, M. Siva Nagi
Kumari, B. Sailaja
Babu, B. Hari
LETTERS IN DRUG DESIGN & DISCOVERY, 2012, 9 (10) : 942 - 946
[43] Molecular docking, synthesis and anticonvulsant activity of some novel 3-(2-substituted)-4-oxothiazolidine-3-yl)-2-phenylquinazoline-4(3H)-ones
Jangam, Sampada S.
Wankhede, Sagar B.
Chitlange, Sohan S.
RESEARCH ON CHEMICAL INTERMEDIATES, 2019, 45 (02) : 471 - 486
[44] Synthesis of 3-Alkoxymethylcoumarin from 3-Cyanochromene via a Novel Intermediate 2-Phenylimino-3-alkoxymethylchromene
Tsai, Jui-Chi
Li, Sie-Rong
Chiang, Michael Y.
Chen, Lian-Yeu
Chen, Po-Yuan
Lo, Yi-Fang
Wang, Chen-Hao
Lin, Chun-Nan
Wang, Eng-Chi
JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (22) : 8798 - 8801
[45] Synthesis and Biological Activity of Novel 2,3-Dihydro-2-phenylsulfonylhydrazono-3-(2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopyranosyl)thiazoles
Wang Hao-an
Li Yu-xin
Li Zheng-ming
Cheng Hai-ying
Wang Su-hua
Liu Bin
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2009, 25 (01) : 52 - 55
[46] De Novo Asymmetric Synthesis of an α-6-Deoxyaltropyranoside as Well as its 2-/3-Deoxy and 2,3-Dideoxy Congeners
Shan, Mingde
Xing, Yalan
O'Doherty, George A.
JOURNAL OF ORGANIC CHEMISTRY, 2009, 74 (16) : 5961 - 5966
[47] The Synthesis of 3H-Labelled 8-Azido-N6-Benzyladenine and Related Compounds for Photoaffinity Labelling of Cytokinin-Binding Proteins
Letham, David. S.
Zhang, Xue-Dong
Hocart, Charles H.
MOLECULES, 2019, 24 (02):
[48] Synthesis, anticancer and antibacterial evaluation of novel (isopropylidene) uridine-[1,2,3]triazole hybrids
Thatipamula, Ranjith Kumar
Narsimha, Sirassu
Battula, Kumaraswamy
Chary, V. Rajendra
Mamidala, Estari
Reddy, Nagavelli Vasudeva
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2017, 21 (07) : 795 - 802
[49] Synthesis and chemical reactivity of the novel 3-chloro-3-(4-chlorocoumarin-3-yl)prop-2-enal
El-Kazak, Azza M.
El-Gohary, Nasser M.
Badran, Al-Shimaa
Ibrahim, Magdy A.
TETRAHEDRON, 2019, 75 (29) : 3923 - 3932
[50] Synthesis of novel 3-(benzothiazol-2-ylmethylene)indolin-2-ones
Zhang, Chao
Xu, Juan
Zhao, Xinyu
Kang, Congmin
JOURNAL OF CHEMICAL RESEARCH, 2017, (09) : 537 - 540

← 1 2 3 4 5 →