Novel Exocyclic Nucleoside Related to Clitocine: A Convergent Synthesis of 3′-Azido-2′,3′-dideoxy Clitocine

被引：6
|
作者：
Guo, Xianghai [1 ,2 ]
Liu, Can [3 ]
Zheng, Lanxi [3 ]
Jiang, Shende [3 ]
Shen, Jiaxiang [3 ]
机构：
[1] Tianjin Univ, Minist Educ, Key Lab Syst Bioengn, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Dept Pharmaceut Engn, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
来源：
SYNLETT | 2010年 / 13期
关键词：
nucleoside analogues; exocyclic nucleosides; convergent synthesis; clitocine; antiviral drug; POTENTIAL ANTIVIRAL DRUGS; INSECTICIDAL NUCLEOSIDE; CARBOCYCLIC CLITOCINE; AMINO NUCLEOSIDE; ADENOSINE KINASE; ANALOGS; INVERSA; OLIGONUCLEOTIDE; INHIBITORS; CELLS;
D O I：
10.1055/s-0030-1258503
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a new clitocine derivative was achieved through a convergent strategy. A protected 4,6-diamino-5-nitropyrimidine was condensed with p-chlorobenzoyl (PCB)-protected methyl 3'-azido-2',3'-dideoxyribofuranoside, followed by subsequently deprotection to give the desired product.
引用
收藏
页码：1959 / 1962
页数：4
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