New 1,3,4-thiadiazoles based on thiophene-2-carboxylic acid: Synthesis, characterization, and antimicrobial activities

被引：20

作者：

Muglu, Halit ^{[1
]}

Yakan, Hasan ^{[2
]}

Shouaib, Hanan Almabrok ^{[3
]}

机构：

[1] Kastamonu Univ, Fac Art & Sci, Dept Chem, Kastamonu, Turkey

[2] Ondokuz Mayis Univ, Fac Educ, Chem Educ, Atakum, Samsun, Turkey

[3] Kastamonu Univ, Fac Sci & Arts, Dept Biol, Kastamonu, Turkey

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2020年 / 1203卷 / 1203期

关键词：

Thiophene-2-carboxylic acid; 1,3,4-Thiadiazoles; N-arylthiosemicarbazides; Antimicrobial activity; Spectroscopic methods; DERIVATIVES SYNTHESIS; ANTICONVULSANT; 1,2,4-TRIAZOLE; ANTIBACTERIAL; 1,3,4-OXADIAZOLES; MOIETY;

D O I：

10.1016/j.molstruc.2019.127470

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Novel 1,3,4-thiadiazole derivatives were prepared by cyclization reaction of thiophene-2-carboxylic acid with N-arylthiosemicarbazides and POCl3. The antibacterial activities of the synthesized compounds were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli), Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans), and the fungus Candida albicans using the disk diffusion method. Selected 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, C. albicans, S. typhimurium, E. aerogenes, and S. kentucky. Therefore, 1,3,4-thiadiazole derivatives can be considered as bioactive agents for pharmacological and medicinal applications. The synthesized compounds were characterized by using IR, H-1 NMR, and C-13 NMR spectroscopies and elemental analysis. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：10

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