Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)

被引：88

作者：

Jacobs, Eric J. ^{[1
]}

Chanock, Stephen J. ^{[2
]}

Fuchs, Charles S. ^{[3
,4
]}

LaCroix, Andrea ^{[6
]}

McWilliams, Robert R. ^{[7
]}

Steplowski, Emily ^{[8
]}

Stolzenberg-Solomon, Rachael Z.

Arslan, Alan A. ^{[9
,10
,11
]}

Bueno-de-Mesquita, H. Bas ^{[12
,13
]}

Gross, Myron ^{[14
]}

Helzlsouer, Kathy ^{[15
]}

Petersen, Gloria ^{[16
]}

Zheng, Wei ^{[17
]}

Agalliu, Ilir ^{[18
]}

Allen, Naomi E. ^{[19
]}

Amundadottir, Laufey ^{[2
]}

Boutron-Ruault, Marie-Christine ^{[20
,21
]}

Buring, Julie E. ^{[5
,22
,23
]}

Canzian, Federico ^{[24
]}

Clipp, Sandra ^{[25
]}

Dorronsoro, Miren

Gaziano, J. Michael ^{[26
,27
]}

Giovannucci, Edward L. ^{[4
,28
,29
]}

Hankinson, Susan E. ^{[4
,29
]}

Hartge, Patricia

Hoover, Robert N.

Hunter, David J. ^{[4
,29
]}

Jacobs, Kevin B. ^{[30
,31
]}

Jenab, Mazda ^{[32
]}

Kraft, Peter ^{[29
]}

Kooperberg, Charles ^{[6
]}

Lynch, Shannon M. ^{[33
]}

Sund, Malin ^{[34
]}

Mendelsohn, Julie B.

Mouw, Tracy ^{[35
]}

Newton, Christina C. ^{[1
]}

Overvad, Kim ^{[36
,37
]}

Palli, Domenico ^{[38
]}

Peeters, Petra H. M. ^{[35
,39
]}

Rajkovic, Aleksandar ^{[40
]}

Shu, Xiao-Ou ^{[17
]}

Thomas, Gilles

Tobias, Geoffrey S.

Trichopoulos, Dimitrios ^{[29
,41
]}

Virtamo, Jarmo ^{[42
]}

Wactawski-Wende, Jean ^{[43
]}

Wolpin, Brian M. ^{[3
,4
]}

Yu, Kai

Zeleniuch-Jacquotte, Anne ^{[10
,11
]}

机构：

[1] Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA

[2] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[3] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[5] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA

[6] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[7] Mayo Clin, Coll Med, Dept Oncol, Rochester, MN USA

[8] Informat Management Serv Inc, Silver Spring, MD USA

[9] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA

[10] NYU, Sch Med, Dept Environm Med, New York, NY USA

[11] NYU, Inst Canc, New York, NY USA

[12] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands

[13] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[14] Univ Minnesota, Sch Med, Dept Lab Med Pathol, Minneapolis, MN 55455 USA

[15] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA

[16] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[17] Vanderbilt Univ, Dept Med, Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[18] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[19] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[20] INSERM, F-75654 Paris 13, France

[21] Inst Gustave Roussy, Villejuif, France

[22] Brigham & Womens Hosp, Dept Med, Div Prevent Med & Aging, Boston, MA 02115 USA

[23] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA

[24] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[25] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA

[26] Brigham & Womens Hosp, Dept Med, Phys Hlth Study, Div Aging Cardiovasc Dis & Prevent Med, Boston, MA 02115 USA

[27] Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA

[28] Harvard Univ, Sch Med, Dept Nutr, Boston, MA USA

[29] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[30] BioInformed LLC, Gaithersburg, MD USA

[31] NCI, Core Genotyping Facil, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21701 USA

[32] Int Agcy Res Canc, F-69372 Lyon, France

[33] NCI, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA

[34] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[35] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[36] Aarhus Univ Hosp, Dept Cardiol, Aalborg Hosp, Aalborg, Denmark

[37] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg Hosp, Aalborg, Denmark

[38] Canc Res & Prevent Inst ISPO Florence, Mol & Nutr Epidemiol Unit, Florence, Italy

[39] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[40] Univ Pittsburgh, Dept Obstet & Gynecol, Pittsburgh, PA USA

[41] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[42] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[43] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA

来源：

INTERNATIONAL JOURNAL OF CANCER | 2010年 / 127卷 / 06期

关键词：

SINGLE BRCA2 MUTATION; COLORECTAL-CANCER; HIGH PREVALENCE; WOMENS HEALTH; BREAST; ADENOCARCINOMA; POLYMORPHISMS; RATIONALE; MORTALITY; RELATIVES;

D O I：

10.1002/ijc.25148

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (Cl) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% Cl = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% Cl = 0.52-1.31), breast cancer (OR = 1.21, 95% Cl = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% Cl = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.

引用

页码：1421 / 1428

页数：8

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