Lag associations of gestational phthalate exposure with maternal serum vitamin D levels: Repeated measure analysis

被引：13

作者：

Gao, Hui ^{[1
,2
,3
]}

Tong, Juan ^{[4
,5
]}

Zhu, Bei-bei ^{[2
,3
,5
]}

Chen, Yao

Ye, Ao-xing ^{[5
]}

Huang, Kun ^{[2
,3
,5
]}

Liang, Chun-mei ^{[3
,5
]}

Wu, Xiao-yan ^{[2
,4
,5
]}

Sheng, Jie ^{[2
,3
,4
]}

Jin, Zhong-xiu ^{[2
,3
,4
]}

Zhu, Peng ^{[2
,3
,4
,5
]}

Hao, Jia-hu ^{[2
,3
,4
,5
]}

Tao, Fang-biao ^{[2
,3
,4
,5
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Pediat, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China

[2] Anhui Med Univ, Key Lab Populat Hlth Life Cycle, Minist Educ Peoples Republ China, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

[3] NHC Key Lab Study Abnormal Gametes & Reprod Tract, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

[4] Anhui Med Univ, Anhui Prov Key Lab Populat Hlth & Aristogen, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

[5] Anhui Med Univ, Sch Publ Hlth, Dept Maternal Child & Adolescent Hlth, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China

来源：

CHEMOSPHERE | 2022年 / 299卷

关键词：

Phthalate; Vitamin D; Lag effect; Repeated measure analysis; Prospective Birth Cohort Study; URINARY CONCENTRATIONS; RISK-ASSESSMENT; PREGNANT-WOMEN; BISPHENOL-A; METABOLITES; PERFORMANCE; HOMEOSTASIS; ACTIVATION; CHILDHOOD; TRIMESTER;

D O I：

10.1016/j.chemosphere.2022.134319

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Few studies have investigated the relationships between gestational phthalate exposure and maternal circulating vitamin D. In the Ma'anshan birth cohort, 3265 pregnant women were included. Each woman provided up to three urine and serum samples for measurement of phthalates and 25(OH)D and calcium, respectively. Linear mixed models were performed to analyse the association between phthalate metabolites and 25(OH)D and calcium. Stratified analyses of the relationship between phthalates and 25(OH)D by urine collection season were conducted. Finally, the post hoc lag effect of phthalate exposure on 25(OH)D was determined if longitudinal associations were significant. Some phthalate metabolites were associated with increased 25(OH)D but with decreased calcium. Furthermore, the relationship of phthalate exposure with 25(OH)D varied with urine collection season. Phthalate metabolites collected in summer and autumn were associated with an increase in 25 (OH)D, while monobenzyl phthalate collected in winter and spring was inversely associated with 25(OH)D. Finally, high-molecular-weight phthalates had lag associations with 25(OH)D with a 1-trimester lag period. Low molecular-weight phthalates exhibited lag associations with 25(OH)D with a 2-trimester lag period. In conclusion, the positive cross-sectional correlation between phthalate metabolites and 25(OH)D was partly affected by urine collection season. This study suggested that gestational phthalate exposure would have a lag association with maternal 25(OH)D levels.

引用

页数：8

共 52 条

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