Evaluation of fetal protection against experimental infection with type 1 and type 2 bovine viral diarrhea virus after vaccination of the dam with a bivalent modified-live virus vaccine

被引:34
作者
Fairbanks, KK
Rinehart, CL
Ohnesorge, C
Loughin, MM
Chase, CCL
机构
[1] Rural Technol Inc, Brookings, SD 57006 USA
[2] Boehringer Ingelheim Vetmed Inc, St Joseph, MO USA
[3] Milliken Associates Inc, Manhattan, KS 66502 USA
[4] S Dakota State Univ, Coll Agr & Biol Sci, Dept Vet Sci, Brookings, SD USA
来源
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION | 2004年 / 225卷 / 12期
关键词
D O I
10.2460/javma.2004.225.1898
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Objective-To evaluate the efficacy of a modified-live virus (MLV) combination vaccine containing type 1 and type 2 bovine viral diarrhea virus (BVDV) in providing fetal protection against challenge with heterologous type 1 and type 2 BVDV Design-Prospective study. Animals-55 heifers. Procedure-Heifers were vaccinated with a commercial MLV combination vaccine or given a sham vaccine (sterile water) and bred 47 to 53 days later. Heifers were challenged with type 1 or type 2 BVDV on days 75 to 79 of gestation. Clinical signs of BVDV infection, presence of viremia, and WBC count were assessed for 14 days after challenge. Fetuses were collected on days 152 to 156 of gestation, and virus isolation was attempted from fetal tissues. Results-Type 1 BVDV was not isolated in any fetuses from vaccinated heifers and was isolated in all fetuses from nonvaccinated heifers challenged with type 1 BVDV Type 2 BVDV was isolated in 1 fetus from a vaccinated heifer and all fetuses from nonvaccinated heifers challenged with type 2 BVDV. Conclusions and Clinical Relevance-A commercial MLV combination vaccine containing type 1 and type 2 BVDV given to the dam prior to breeding protected 100% of fetuses against type 1 BVDV infection and 95% of fetuses against type 2 BVDV infection. Use of a bivalent MLV vaccine in combination with a comprehensive BVDV control program should result in decreased incidence of persistent infection in calves and therefore minimize the risk of BVDV infection in the herd.
引用
收藏
页码:1898 / 1904
页数:7
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