Cannabinoid agonist-induced sensitisation to morphine place preference in mice

被引：53

作者：

Manzanedo, C

Aguilar, MA

Rodriguez-Arias, M

Navarro, M

Miñarro, J

机构：

[1] Univ Valencia, Fac Psicol, Dept Psicobiol, Valencia 46010, Spain

[2] Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, Madrid 28223, Spain

来源：

NEUROREPORT | 2004年 / 15卷 / 08期

关键词：

cannabinoid; conditioned place preference; mice; morphine; opioids; sensitisation; SR; 141716A; WIN 55,212-2;

D O I：

10.1097/01.wnr.0000126217.87116.8c

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of the endocannabinoid system on the sensitisation to the rewarding effects of morphine in the place conditioning paradigm was evaluated. In mice pretreated with morphine this drug induces place preference with lower doses. Pretreatment with non-rewarding doses of the cannabinoid agonist WIN 55,2122 (0.5 and 1 mg/kg) induces sensitisation to the rewarding effects of morphine. However, the pretreatment with the cannabinoid antagonist SR 144716A plus morphine or WIN 55,212-2 blocks it. Our results suggest the existence of cross-talk between cannabinoids and opiates on the sensitisation to morphine and the implication of the endocannabinoid system in the process of sensitisation to opiates.

引用

页码：1373 / 1377

页数：5

共 24 条

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