Domino ring-opening/recyclization reactions of doubly activated cyclopropanes as a strategy for the synthesis of furoquinoline derivatives

被引：113

作者：

Zhang, Zhiguo ^{[1
]}

Zhang, Qian ^{[1
]}

Sun, Shaoguang ^{[1
]}

Xiong, Tao ^{[1
]}

Liu, Qun ^{[1
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 10期

关键词：

cyclization; cyclopropanes; domino reactions; furoquinolines; synthetic methods;

D O I：

10.1002/anie.200604276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) In one easy step, doubly activated cyclopropanes 1 can be transformed into furoquinoline derivatives 2 through a tandem ring-opening/recyclization reaction mediated by SnCl4·5 H2O. A variety of substrates 1 derived from cheap starting materials were converted into the corresponding furoquinolines in good to excellent yields with high chemo- and regioselectivity. R = H, Me, OMe, Cl, or aromatic group is naphthyl. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1726 / 1729

页数：4

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