Relationship between Serum Levels of Tau Fragments and Clinical Progression of Alzheimer's Disease

被引：28
作者：
Henriksen, Kim [1 ]
Byrjalsen, Inger [1 ]
Christiansen, Claus [1 ]
Karsdal, Morten Asser [1 ]
机构：
[1] Nord Biosci Biomarkers & Res, Herlev, Denmark
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 43卷 / 04期
关键词：
Alzheimer's disease; biomarkers; prediction; serum; tau; NEUROFIBRILLARY TANGLES; CASPASE-CLEAVAGE; BIOMARKERS; AGGREGATION; COLLAGEN; PROTEIN; MARKER; SCALE;
D O I：
10.3233/JAD-140984
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Enzyme-generated fragments of tau have been linked to neuronal death and may serve as serum biomarkers of cognitive loss. Two competitive ELISAs detecting an ADAM10-generated fragment (Tau-A) or a caspase-3-generated fragment (Tau-C) were measured in baseline serum samples from patients with mild to moderate Alzheimer's disease (AD) from a Phase III clinical trial, and correlated to change in the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog11) and Clinical Dementia Rating-Sum of Boxes (CDR-SB) over a 64-week period using an MMRM-analysis. Relationship between the biomarkers and changes in ADAS-Cog11 score as a function of time were observed for Tau-C and change in ADAS-Cog11 (p = 0.06), and for Tau-A and change in CDR-SB (p = 0.04). The correlation of Tau-A/Tau-C ratio with cognitive change assessed by ADAS-Cog11 was even more significant (p<0.006). These data indicate that measuring the balance between tau fragments in serum may provide a marker of the rate of progression of AD and warrant studies in larger cohorts.
引用
收藏
页码：1331 / 1341
页数：11
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