Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

被引：22

作者：

Lu, Yue ^{[1
,2
,3
,4
]}

Mo, Ran ^{[1
,2
,3
,4
]}

Tai, Wanyi ^{[1
,2
,3
,4
]}

Sun, Wujin ^{[1
,2
,3
,4
]}

Pacardo, Dennis B. ^{[1
,2
,3
,4
]}

Qian, Chenggen ^{[1
,2
,3
,4
,5
]}

Shen, Qundong ^{[5
]}

Ligler, Frances S. ^{[1
,2
]}

Gu, Zhen ^{[1
,2
,3
,4
]}

机构：

[1] Univ N Carolina, Joint Dept Biomed Engn, Chapel Hill, NC 27514 USA

[2] N Carolina State Univ, Raleigh, NC 27695 USA

[3] Univ N Carolina, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC USA

[4] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC USA

[5] Nanjing Univ, Dept Polymer Sci & Engn, Sch Chem & Chem Engn, Nanjing 210008, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 95期

关键词：

POLYMERIC MICELLES; POLY(ETHYLENE GLYCOL); GENE DELIVERY; PH; REDUCTION; DOXORUBICIN; CELLS; MACROPINOCYTOSIS; NANOPARTICLES; TRANSFECTION;

D O I：

10.1039/c4cc07004f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Self-folded redox/acid dual-responsive nanocarriers (RAD-NCs) are developed for physiologically triggered delivery of anticancer drugs. The evidenced redox/acid responsiveness, facile decoration of ligands, and active tumor-targeting capability of RAD-NCs suggest their potential as a promising formulation for tumor-targeted chemotherapy.

引用

页码：15105 / 15108

页数：4

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