Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

被引：270

作者：

Gillet, Nicolas

Florins, Arnaud

Boxus, Mathieu

Burteau, Catherine

Nigro, Annamaria

Vandermeers, Fabian

Balon, Herve

Bouzar, Amel-Baya

Defoiche, Julien

Burny, Arsene

Reichert, Michal

Kettmann, Richard

Willems, Luc ^{[1
]}

机构：

[1] Fac Univ Sci Agron, Gembloux, Belgium

[2] Natl Inst Vet Res, Pulawy, Poland

[3] Natl Fund Sci Res, Mol & Cellular Biol Lab, B-5030 Gembloux, Belgium

来源：

RETROVIROLOGY | 2007年 / 4卷 / 1期

关键词：

D O I：

10.1186/1742-4690-4-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.

引用

页数：32

共 361 条

[1] Valproate activates bovine leukemia virus gene expression, triggers apoptosis, and induces leukemia/lymphoma regression in vivo [J].