Sequence-specific 1H, 13C and 15N backbone resonance assignments of the plakin repeat domain of human envoplakin

被引：0
|
作者：
Jeeves, Mark [1 ]
Fogl, Claudia [1 ]
Al-Jassar, Caezar [2 ,3 ]
Chidgey, Martyn [3 ]
Overduin, Michael [1 ,4 ]
机构：
[1] Univ Birmingham, Henry Wellcome Bldg Biomol NMR Spect, Birmingham B15 2TT, W Midlands, England
[2] MRC Lab Mol Biol, Francis Crick Ave, Cambridge CB2 0QH, England
[3] Univ Birmingham, Sch Canc Sci, Birmingham B15 2TT, W Midlands, England
[4] Univ Alberta, Fac Med & Dent, Dept Biochem, 474 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada
来源：
BIOMOLECULAR NMR ASSIGNMENTS | 2016年 / 10卷 / 01期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
Envoplakin; Plakin repeat domain; Cornified envelope; Plakin; Cytoskeleton; Backbone resonance assignment; RIGHT-VENTRICULAR DYSPLASIA; CORNIFIED ENVELOPE; DESMOPLAKIN; NMR; SKIN; MODEL;
D O I：
10.1007/s12104-015-9659-2
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
The plakin repeat domain is a distinctive hallmark of the plakin superfamily of proteins, which are found within all epithelial tissues. Plakin repeat domains mediate the interactions of these proteins with the cell cytoskeleton and are critical for the maintenance of tissue integrity. Despite their biological importance, no solution state resonance assignments are available for any homologue. Here we report the essentially complete H-1, C-13 and N-15 backbone chemical shift assignments of the singular 22 kDa plakin repeat domain of human envoplakin, providing the means to investigate its interactions with ligands including intermediate filaments.
引用
收藏
页码：167 / 170
页数：4
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