From adenosine to 3′-deoxyadenosine:: Development and scale up

被引：29

作者：

Aman, S ^{[1
]}

Anderson, DJ ^{[1
]}

Connolly, TJ ^{[1
]}

Crittall, AJ ^{[1
]}

Ji, GJ ^{[1
]}

机构：

[1] Raylo Chem Inc, Edmonton, AB T6C 4A9, Canada

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2000年 / 4卷 / 06期

关键词：

D O I：

10.1021/op000209x

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A manufacturing process has been developed suitable for the production of 3'-deoxyadenosine (cordycepin, 3'-dA) in 20% yield from adenosine, The chemistry involves conversion of adenosine to isomeric 2',3'-bromoacetates with isolation of the desired isomer in high purity. Acidic hydrolysis followed by hydrogenolysis afforded product with a purity of greater than or equal to 99%, Unlike routes reported in the literature, intermediates are isolated as solids, thus avoiding the use of chromatography for isomer separation and final product purification.

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页码：601 / 605

页数：5

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