Up-regulation of caveolin expression by cytotoxic agents in drug-sensitive cancer cells

被引：40
作者：
Bélanger, MM [1 ]
Roussel, É [1 ]
Couet, J [1 ]
机构：
[1] Univ Laval, Ctr Lecherche Hop Laval, Unite Rech Pneumol, Inst Univ Cardiol & Pneumol, Ste Foy, PQ G1V 4G5, Canada
来源：
ANTI-CANCER DRUGS | 2003年 / 14卷 / 04期
关键词：
caveolae; caveolin; cytotoxic drug; multidrug resistance;
D O I：
10.1097/00001813-200304000-00005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Caveolin 1 expression is down-regulated in various cancer cell lines. Interestingly, in several drug-resistant cancer cells, a strong induction of caveolin 1 expression has been reported, suggesting a role for caveolin 1 in the acquisition and/or the maintenance of the multidrug-resistance phenotype. Here, we show, in drug-sensitive lung cancer cells (A549, Calu-6 or NCl-H69), that exposure to cytotoxic drugs (taxol, doxorubicin or etoposide) is sufficient to strongly up-regulate caveolin 1 and 2 protein levels. This up-regulation is sustained even 1 week after drug removal. Our results suggest that caveolin up-regulation is an early cellular response to a cytotoxic stress taking place before drug resistance.
引用
收藏
页码：281 / 287
页数：7
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