Diversity-Oriented Synthesis of Steviol Glycosides

被引：13

作者：

Qiao, Zhi ^{[1
]}

Liu, Hui ^{[1
]}

Sui, Jing-Jing ^{[1
]}

Liao, Jin-Xi ^{[1
]}

Tu, Yuan-Hong ^{[1
]}

Schmidt, Richard R. ^{[1
,2
]}

Sun, Jian-Song ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, 99 Ziyang Ave, Nanchang 330022, Jiangxi, Peoples R China

[2] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 19期

基金：

中国国家自然科学基金;

关键词：

HIGHLY EFFICIENT SYNTHESIS; GLYCOSYLATION; DONORS; OLIGOSACCHARIDES; ALKYNYLBENZOATES; REBAUDIANA; SWEETENER; LINKAGES; SAPONINS; TASTE;

D O I：

10.1021/acs.joc.8b01274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With cheap and easily available mixtures of steviol glycosides as starting materials, a practical method for steviol acquisition has been developed, on the basis of which a facile, diversity-oriented, and economic protocol for the synthesis of structurally defined steviol glycosides was established. The novel approach is featured by the highly efficient glycosylation of sterically hindered and acid-sensitive steviol via orchestrated application of Yu glycosylation, Schmidt glycosylation, and PTC glycosylation. Hence, these high-intensity sweeteners and potential lead compounds for drug development are now readily accessible.

引用

页码：11480 / 11492

页数：13

共 39 条

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