Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles

被引：214

作者：

Zhu, Lei ^{[1
]}

Yu, Yinghua ^{[1
]}

Mao, Zhifeng ^{[1
]}

Huang, Xueliang ^{[1
]}

机构：

[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 01期

基金：

中国国家自然科学基金;

关键词：

HIGHLY SUBSTITUTED PYRROLES; FORMAL 3+2 CYCLOADDITION; DIAZO OXIME ETHERS; TERMINAL ALKYNES; VINYL AZIDES; DERIVATIVES; ACCESS; REARRANGEMENT; CYCLIZATION; OXIDANTS;

D O I：

10.1021/ol503172h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective gold-catalyzed intermolecular nitrene transfer by the reaction of 2H-azirines and ynamides is reported, which provides highly substituted pyrroles in a straightforward manner. This transformation proceeds under mild conditions and gives the polysubstituted pyrroles in good-to-excellent yields. Preliminary results indicate that a nongold carbenoid pathway is preferred for current pyrrole synthesis.

引用

页码：30 / 33

页数：4

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