Peanut Allergy: Changes in Dogma and Past, Present, and Future Directions

被引:2
作者
Boudreau-Romano, Sarah [1 ]
Qamar, Nashmia [1 ]
机构
[1] Ann & Robert H Lurie Childrens Hosp Chicago, Div Allergy & Immunol, Dept Pediat, Pediat, Chicago, IL 60611 USA
来源
PEDIATRIC ANNALS | 2018年 / 47卷 / 07期
关键词
ORAL IMMUNOTHERAPY; FILAGGRIN GENE; FOOD ALLERGY; DOUBLE-BLIND; RISK; CHILDREN; DESENSITIZATION; INFANTS;
D O I
10.3928/19382359-20180621-02
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The prevalence of food allergy in the pediatric population, specifically to peanuts, has been rising. Accidental exposure to peanuts in a person who is allergic may have life-threatening consequences. Previous recommendations regarding peanut allergy included a delay in introduction of peanut to infants. However, more recent studies have provided sufficient contrary evidence supporting early introduction of peanuts for prevention of peanut allergy. Therefore, prompt evaluation by a specialist should be considered in infants at high risk of developing peanut allergy. Current treatment is strict avoidance of the allergen; however, future therapies are being sought, including oral immunotherapy, sublingual immunotherapy, and epicutaneous immunotherapy. [Pediatr Ann. 2018;47(7):e300-e304.]
引用
收藏
页码:E300 / E304
页数:5
相关论文
共 31 条
[1]   Immunological mechanisms of sublingual immunotherapy [J].
Akdis, C. A. ;
Barlan, I. B. ;
Bahceciler, N. ;
Akdis, M. .
ALLERGY, 2006, 61 :11-14
[3]   Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status [J].
Asai, Yuka ;
Greenwood, Celia ;
Hull, Peter R. ;
Alizadehfar, Reza ;
Ben-Shoshan, Moshe ;
Brown, Sara J. ;
Campbell, Linda ;
Michel, Deborah L. ;
Bussieres, Johanne ;
Rousseau, Francois ;
Fujiwara, T. Mary ;
Morgan, Kenneth ;
Irvine, Alan D. ;
McLean, W. H. Irwin ;
Clarke, Ann .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (01) :239-242
[4]  
Baker SS, 2000, PEDIATRICS, V106, P346
[5]   Further fatalities caused by anaphylactic reactions to food, 2001-2006 [J].
Bock, S. Allan ;
Munoz-Furlong, Anne ;
Sampson, Hugh A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (04) :1016-1018
[6]   Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy [J].
Brown, Sara J. ;
Asai, Yuka ;
Cordell, Heather J. ;
Campbell, Linda E. ;
Zhao, Yiwei ;
Liao, Haihui ;
Northstone, Kate ;
Henderson, John ;
Alizadehfar, Reza ;
Ben-Shoshan, Moshe ;
Morgan, Kenneth ;
Roberts, Graham ;
Masthoff, Laury J. N. ;
Pasmans, Suzanne G. M. A. ;
van den Akker, Peter C. ;
Wijmenga, Cisca ;
Hourihane, Jonathan O'B. ;
Palmer, Colin N. A. ;
Lack, Gideon ;
Clarke, Ann ;
Hull, Peter R. ;
Irvine, Alan D. ;
McLean, W. H. Irwin .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (03) :661-667
[7]   Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy [J].
Du Toit, George ;
Roberts, Graham ;
Sayre, Peter H. ;
Bahnson, Henry T. ;
Radulovic, Suzana ;
Santos, Alexandra F. ;
Brough, Helen A. ;
Phippard, Deborah ;
Basting, Monica ;
Feeney, Mary ;
Turcanu, Victor ;
Sever, Michelle L. ;
Lorenzo, Margarita Gomez ;
Plaut, Marshall ;
Lack, Gideon .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (09) :803-813
[8]   Food allergy and the introduction of solid foods to infants: a consensus document [J].
Fiocchi, Alessandro ;
Assa'ad, Amal ;
Bahna, Sami .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2006, 97 (01) :10-20
[9]   Suppression of the immunologic response to peanut during immunotherapy is often transient [J].
Gorelik, Mark ;
Narisety, Satya D. ;
Guerrerio, Anthony L. ;
Chichester, Kristin L. ;
Keet, Corinne A. ;
Bieneman, Anja P. ;
Hamilton, Robert G. ;
Wood, Robert A. ;
Schroeder, John T. ;
Frischmeyer-Guerrerio, Pamela A. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2015, 135 (05) :1283-1292
[10]  
Illinois State Board of Education, ILL FOOD ALL EM ACT