Pre-/post-functionalization in dipyrrin metal complexes - antitumor and antibacterial activity of their glycosylated derivatives

被引：22

作者：

Gutsche, Claudia S. ^{[1
,2
,3
]}

Graefe, Susanna ^{[3
]}

Gitter, Burkhard ^{[3
]}

Flanagan, Keith J. ^{[4
]}

Senge, Mathias O. ^{[4
]}

Kulak, Nora ^{[1
]}

Wiehe, Arno ^{[2
,3
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 34-36, D-14195 Berlin, Germany

[2] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany

[3] Biolitec Res GmbH, Otto Schott Str 15, D-07745 Jena, Germany

[4] Univ Dublin, St Jamess Hosp, Trinity Translat Med Inst, Med Chem,Trinity Ctr Hlth Sci,Trinity Coll Dublin, Dublin 8, Ireland

来源：

DALTON TRANSACTIONS | 2018年 / 47卷 / 35期

基金：

欧盟地平线“2020”; 爱尔兰科学基金会;

关键词：

ORGANIC FRAMEWORKS; GALLIUM COMPLEXES; RUTHENIUM; PORPHYRINS; LIGANDS; CANCER; PHTHALOCYANINES; CHROMOPHORES; SUBSTITUTION; SENSITIZERS;

D O I：

10.1039/c8dt03059f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A post-functionalization route to tris(dipyrrinato) metal complexes is presented giving access to a range of new complexes relevant in the context of medicinal inorganic chemistry. A pentafluorophenyl group in the meso-position of the dipyrrin ligand serves as an anchor for the connection with alcohols and thiocarbohydrates. The photochemotherapeutic activity of the complexes has been assessed in cellular assays with tumor cell lines and against the Gram-positive bacterium S. aureus. Finally, it is shown that this post-functionalization is also applicable to other dipyrrinato metal complexes.

引用

页码：12373 / 12384

页数：12

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