Solution chemistry and cytotoxic properties of novel organogold(III) compounds

被引：69

作者：

Messori, L

Marcon, G

Cinellu, MA

Coronnello, M

Mini, E

Gabbiani, C

Orioli, P

机构：

[1] Univ Florence, Dept Chem, I-50019 Florence, Italy

[2] Univ Sassari, Dept Chem, I-07100 Sassari, Italy

[3] Univ Florence, Dept Pharmacol, I-50139 Florence, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 23期

关键词：

organogold(III) complexes; UV-vis absorption spectroscopy; H-1 NMR spectroscopy; cytotoxicity; gold; cancer;

D O I：

10.1016/j.bmc.2004.09.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The solution behaviour of some novel organogold(III) compounds was investigated, and their cytotoxic properties evaluated against a few human tumour cell lines (A2780/S, A2780/R, MCF7, HT29 and A549). Specifically, the following compounds were considered: [Au(bipy(dmb)-H)(2,6-xylidine-H)][PF6] (AuXyl) and [Au(bipy(dmb)-H)(P-toluidine-H)][PF6] (AuTol) (in which bipy(dmb) = 6-(1,1-dimethylbenzyl)-2,2'-bipyridine), [Au(py(dmb)-H)(AcO)(2)] (AuPyAcO) (in which py(dmb) = 2-(1,1-dimethylbenzyl)-pyridine) and [Au(pz(Ph)-H)Cl-3]K (AuPzCl) (in which Pz(Ph) = 1-phenylpyrazole). The solution chemistry of these compounds, under physiological-like conditions, was investigated through UV-vis absorption and H-1 NMR spectroscopies. Significant cytotoxic effects in vitro were observed in selected cases. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：6039 / 6043

页数：5

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