Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine

被引：18

作者：

Bandari, Suresh ^{[1
]}

Eaga, Chandra Mohan ^{[1
]}

Thadishetty, Ashok ^{[1
]}

Yamsani, Madhusudan Rao ^{[1
]}

机构：

[1] Kakatiya Univ, Univ Coll Pharmaceut Sci, Ctr Biopharmaceut & Pharmacokinet, Warangal 506009, Andhra Pradesh, India

来源：

ACTA PHARMACEUTICA | 2010年 / 60卷 / 01期

关键词：

biphasic release; gastroretention; multiple matrix tablet; release kinetics; DOSAGE FORMS; RELEASE;

D O I：

10.2478/v10007-010-0001-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L-1 HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.

引用

页码：89 / 97

页数：9

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