Valsartan treatment reverses erectile dysfunction in diabetic rats

被引：20

作者：

Chen, Y.

Li, S. X.

Yao, L. S.

Wang, R.

Dai, Y. T. ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Urol, Nanjing 210008, Peoples R China

[2] Univ Texas, Med Sch Houston, Dept Urol, Houston, TX USA

[3] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2007年 / 19卷 / 04期

关键词：

diabetes mellitus; erectile dysfunction; angiotensin II; angiotensin type 1 receptor; valsartan; intracavernous pressure;

D O I：

10.1038/sj.ijir.3901534

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In order to investigate the effect of angiotensin receptor blockage (ARB) for the treatment on diabetic erectile dysfunction (ED), we used male Sprague - Dawley rats injected with 65 mg/kg streptozotocin to induce diabetes mellitus. The diabetic rats with ED were selected by hypodermic injection of apomorphine (APO) after 8 weeks of model setting. All rats were divided into four groups: G1 ( normal control rats), G2 ( diabetic rats treated with normal saline), G3 ( diabetic rats treated with valsartan) and G4 ( diabetic rats treated with spironolactone). After treatment with drugs for 8 weeks, the rate of erection for each group was evaluated after the injection of APO. The intracavernous pressure (ICP) of each rat was then recorded before and after the electrostimulation of the major pelvic ganglion. The rates of erection and the ICP after electrostimulation for diabetic rats treated with valsartan were significantly higher than that in diabetic rats treated with normal saline and spironolactone. The ARB may be an effective therapy for diabetics with ED.

引用

页码：366 / 370

页数：5

共 23 条

[1] Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction [J].