Cognitive dysfunction in schizophrenia: An expert group paper on the current state of the art

被引：88

作者：

Harvey, Philip D. ^{[1
]}

Bosia, Marta ^{[2
]}

Cavallaro, Roberto ^{[2
]}

Howes, Oliver D. ^{[3
,4
]}

Kahn, Rene S. ^{[5
]}

Leucht, Stefan ^{[6
]}

Mueller, Daniel R. ^{[7
]}

Penades, Rafael ^{[8
]}

Vita, Antonio ^{[9
,10
]}

机构：

[1] Univ Miami, Dept Psychiat, Div Psychol, Miller Sch Med, Miami, FL 33136 USA

[2] Univ Vita Salute San Raffaele, Sch Med, Milan, Italy

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[4] Imperial Coll London, MRC London Inst Med Sci, London, England

[5] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

[6] Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Sect Evidence Based Med Psychiat & Psychotherapy, Munich, Germany

[7] Univ Bern, Univ Hosp Psychiat & Psychotherapy, Bern, Switzerland

[8] Univ Barcelona, Hosp Clin Barcelona, Dept Psychiat & Psychol, IDIBAPS,CIBERSAM, 170 Villarroel St, Barcelona 08036, Spain

[9] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

[10] Spedali Civili Hosp, Dept Mental Hlth & Addict Serv, Brescia, Italy

来源：

SCHIZOPHRENIA RESEARCH-COGNITION | 2022年 / 29卷

关键词：

Psychosis; Neurocognition; Social cognition; Prediction; Daily functioning; Cognitive remediation; Neuroimaging; INTERVIEW-BASED ASSESSMENT; CLINICAL HIGH-RISK; 1ST-EPISODE SCHIZOPHRENIA; INTELLECTUAL ABILITY; REMEDIATION THERAPY; TREATMENT RESISTANCE; ENHANCEMENT THERAPY; CORTICAL THICKNESS; METABOLIC SYNDROME; GLOBAL ASSESSMENT;

D O I：

10.1016/j.scog.2022.100249

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in the domain of cognitive impairment to address cognitive impairments and their consequences in the most effective way. We report on the onset and course of cognitive deficits, linking them to the alterations in brain function and structure in schizophrenia and discussing their role in predicting the transition to psychosis in people at risk. We then address the assessment tools with reference to functioning and social cognition, examining the role of subjective measures and addressing new methods for measuring functional outcomes including technology based approaches. Finally, we briefly review treatment options for cognitive deficits, focusing on cognitive remediation programs, highlighting their effects on brain activity and conclude with the potential benefit of individualized integrated interventions combing cognitive remediation with other approaches.

引用

页数：13

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