Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

被引：38
|
作者：
Lum, Ching Tung [1 ,2 ]
Liu, Xiong [1 ,2 ,3 ]
Sun, Raymond Wai-Yin [1 ,2 ]
Li, Xiang-Ping [3 ]
Peng, Ying [4 ]
He, Ming-Liang [5 ]
Kung, Hsiang Fu [5 ,6 ]
Che, Chi-Ming [1 ,2 ]
Lin, Marie C. M. [1 ,2 ,6 ]
机构：
[1] Univ Hong Kong, Dept Chem, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
[3] Nanfang Med Univ, Nanfang Hosp, Dept Otolaryngol, Guangzhou 510515, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 2, Dept Neurol, Guangzhou 510120, Guangdong, Peoples R China
[5] Chinese Univ Hong Kong, Ctr Emerging Infect Dis, Shatin, Hong Kong, Peoples R China
[6] Sun Yat Sen Univ, State Key Lab Oncol So China, Ctr Canc, Guangzhou 510120, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2010年 / 294卷 / 02期
关键词：
Gold(III) porphyrin 1a; Nasopharyngeal carcinoma (NPC); Metastasis; Cell migration; Invasion; HEPATOCELLULAR-CARCINOMA; INDUCED APOPTOSIS; BREAST-CANCER; DNA-BINDING; ANTICANCER; COMPLEXES; CYTOTOXICITY; EXPRESSION; CISPLATIN; GROWTH;
D O I：
10.1016/j.canlet.2010.01.033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-la markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-la inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：159 / 166
页数：8
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