共 14 条
Angiogenesis induced by the implantation of self-bone marrow cells: A new material for therapeutic angiogenesis
被引:85
作者:

Hamano, K
论文数: 0 引用数: 0
h-index: 0
机构: Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan

Li, TS
论文数: 0 引用数: 0
h-index: 0
机构: Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan

Kobayashi, T
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h-index: 0
机构: Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan

Kobayashi, S
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h-index: 0
机构: Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan

Matsuzaki, M
论文数: 0 引用数: 0
h-index: 0
机构: Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan

Esato, K
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h-index: 0
机构: Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan
机构:
[1] Yamaguchi Univ, Sch Med, Dept Surg 1, Yamaguchi 7558505, Japan
[2] Yamaguchi Univ, Sch Med, Dept Physiol 1, Yamaguchi 7558505, Japan
[3] Yamaguchi Univ, Sch Med, Dept Internal Med 2, Yamaguchi 7558505, Japan
关键词:
angiogenesis;
bone marrow cells;
ischemia;
D O I:
10.1177/096368970000900315
中图分类号:
Q813 [细胞工程];
学科分类号:
摘要:
Bone marrow contains various primitive cells that are thought to secrete several angiogenic growth factors and may also differentiate into endothelial cells. The present study was conducted to investigate the possibility that bone marrow cells could be a novel material to induce angiogenesis. The expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in rat bone marrow cells was examined by immunohistochemistry. The production of VEGF was compared in tissue culture supernatant under the conditions of normoxia and hypoxia. The process of angiogenesis that occurred following the implantation of bone marrow cells was determined using a rat cornea model. VEGF- and bFGF-positive cells were found in rat bone marrow. The production of VEGF from bone marrow cells was significantly more enhanced by hypoxic conditions than by normoxic conditions. The rat cornea model showed that bone marrow cell implantation created new vessels. The implantation of self-bone marrow cells is a novel and simple method of inducing angiogenesis.
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页码:439 / 443
页数:5
相关论文
共 14 条
[1]
Isolation of putative progenitor endothelial cells for angiogenesis
[J].
Asahara, T
;
Murohara, T
;
Sullivan, A
;
Silver, M
;
vanderZee, R
;
Li, T
;
Witzenbichler, B
;
Schatteman, G
;
Isner, JM
.
SCIENCE,
1997, 275 (5302)
:964-967

Asahara, T
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Murohara, T
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Sullivan, A
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Silver, M
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

vanderZee, R
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Li, T
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Witzenbichler, B
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Schatteman, G
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, SCH MED, ST ELIZABETHS MED CTR, DEPT MED CARDIOL, BOSTON, MA 02135 USA
[2]
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
[J].
Asahara, T
;
Masuda, H
;
Takahashi, T
;
Kalka, C
;
Pastore, C
;
Silver, M
;
Kearne, M
;
Magner, M
;
Isner, JM
.
CIRCULATION RESEARCH,
1999, 85 (03)
:221-228

Asahara, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Masuda, H
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Takahashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Kalka, C
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Pastore, C
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Silver, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Kearne, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Magner, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med Cardiol, Boston, MA 02135 USA
[3]
Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology
[J].
Banks, RE
;
Forbes, MA
;
Kinsey, SE
;
Stanley, A
;
Ingham, E
;
Walters, C
;
Selby, PJ
.
BRITISH JOURNAL OF CANCER,
1998, 77 (06)
:956-964

Banks, RE
论文数: 0 引用数: 0
h-index: 0
机构:
St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England

Forbes, MA
论文数: 0 引用数: 0
h-index: 0
机构: St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England

Kinsey, SE
论文数: 0 引用数: 0
h-index: 0
机构: St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England

Stanley, A
论文数: 0 引用数: 0
h-index: 0
机构: St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England

Ingham, E
论文数: 0 引用数: 0
h-index: 0
机构: St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England

Walters, C
论文数: 0 引用数: 0
h-index: 0
机构: St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England

Selby, PJ
论文数: 0 引用数: 0
h-index: 0
机构: St James Univ Hosp, Imperial Canc Res Fund, Canc Med Res Unit, Leeds LS9 7TF, W Yorkshire, England
[4]
Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
[J].
Baumgartner, I
;
Pieczek, A
;
Manor, O
;
Blair, R
;
Kearney, M
;
Walsh, K
;
Isner, JM
.
CIRCULATION,
1998, 97 (12)
:1114-1123

Baumgartner, I
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA

Pieczek, A
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA

Manor, O
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA

Blair, R
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA

Kearney, M
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA

Walsh, K
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: Tufts Univ, St Elizabeths Med Ctr, Sch Med, Dept Med, Boston, MA 02135 USA
[5]
ANGIOGENIC FACTORS
[J].
FOLKMAN, J
;
KLAGSBRUN, M
.
SCIENCE,
1987, 235 (4787)
:442-447

FOLKMAN, J
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA

KLAGSBRUN, M
论文数: 0 引用数: 0
h-index: 0
机构: HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
[6]
Therapeutic angiogenesis in ischemic limbs
[J].
Folkman, J
.
CIRCULATION,
1998, 97 (12)
:1108-1110

Folkman, J
论文数: 0 引用数: 0
h-index: 0
机构: Childrens Hosp, Boston, MA 02115 USA
[7]
TUMOR-GROWTH AND NEOVASCULARIZATION - EXPERIMENTAL MODEL USING RABBIT CORNEA
[J].
GIMBRONE, MA
;
COTRAN, RS
;
LEAPMAN, SB
;
FOLKMAN, J
.
JOURNAL OF THE NATIONAL CANCER INSTITUTE,
1974, 52 (02)
:413-427

GIMBRONE, MA
论文数: 0 引用数: 0
h-index: 0
机构:
CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115 CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115

COTRAN, RS
论文数: 0 引用数: 0
h-index: 0
机构:
CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115 CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115

LEAPMAN, SB
论文数: 0 引用数: 0
h-index: 0
机构:
CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115 CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115

FOLKMAN, J
论文数: 0 引用数: 0
h-index: 0
机构:
CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115 CHILDRENS HOSP,MED CTR,DEPT SURG,BOSTON,MA 02115
[8]
VASCULAR ENDOTHELIAL GROWTH-FACTOR IS A SECRETED ANGIOGENIC MITOGEN
[J].
LEUNG, DW
;
CACHIANES, G
;
KUANG, WJ
;
GOEDDEL, DV
;
FERRARA, N
.
SCIENCE,
1989, 246 (4935)
:1306-1309

LEUNG, DW
论文数: 0 引用数: 0
h-index: 0
机构: GENENTECH INC,DEPT DEV BIOL,S SAN FRANCISCO,CA 94080

CACHIANES, G
论文数: 0 引用数: 0
h-index: 0
机构: GENENTECH INC,DEPT DEV BIOL,S SAN FRANCISCO,CA 94080

KUANG, WJ
论文数: 0 引用数: 0
h-index: 0
机构: GENENTECH INC,DEPT DEV BIOL,S SAN FRANCISCO,CA 94080

GOEDDEL, DV
论文数: 0 引用数: 0
h-index: 0
机构: GENENTECH INC,DEPT DEV BIOL,S SAN FRANCISCO,CA 94080

FERRARA, N
论文数: 0 引用数: 0
h-index: 0
机构: GENENTECH INC,DEPT DEV BIOL,S SAN FRANCISCO,CA 94080
[9]
Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells
[J].
Namiki, A
;
Brogi, E
;
Kearney, M
;
Kim, EA
;
Wu, TG
;
Couffinhal, T
;
Varticovski, L
;
Isner, JM
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1995, 270 (52)
:31189-31195

Namiki, A
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Brogi, E
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Kearney, M
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Kim, EA
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Wu, TG
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Couffinhal, T
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Varticovski, L
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA

Isner, JM
论文数: 0 引用数: 0
h-index: 0
机构: TUFTS UNIV, ST ELIZABETHS MED CTR, SCH MED, DEPT MED CARDIOL, BOSTON, MA 02135 USA
[10]
Autocrine angiogenic vascular prosthesis with bone marrow transplantation
[J].
Noishiki, Y
;
Tomizawa, Y
;
Yamane, Y
;
Matsumoto, A
.
NATURE MEDICINE,
1996, 2 (01)
:90-93

Noishiki, Y
论文数: 0 引用数: 0
h-index: 0
机构: TOKYO WOMENS MED COLL,DEPT CARDIOVASC SURG,SHINJUKU KU,TOKYO 162,JAPAN

Tomizawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: TOKYO WOMENS MED COLL,DEPT CARDIOVASC SURG,SHINJUKU KU,TOKYO 162,JAPAN

Yamane, Y
论文数: 0 引用数: 0
h-index: 0
机构: TOKYO WOMENS MED COLL,DEPT CARDIOVASC SURG,SHINJUKU KU,TOKYO 162,JAPAN

Matsumoto, A
论文数: 0 引用数: 0
h-index: 0
机构: TOKYO WOMENS MED COLL,DEPT CARDIOVASC SURG,SHINJUKU KU,TOKYO 162,JAPAN