Multistep Microchemical Synthesis Enabled by Microfluidic Distillation

被引：123
作者：
Hartman, Ryan L. [2 ]
Naber, John R. [1 ]
Buchwald, Stephen L. [1 ]
Jensen, Klavs F. [2 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 05期
关键词：
Heck reaction; microfluidic distillation; microreactors; palladium; synthetic methods; PALLADIUM-CATALYZED ARYLATION; HECK REACTION; ALPHA-REGIOSELECTIVITY; ORGANIC-SYNTHESIS; FLOW; HYDROGENATION; EVAPORATION; REACTORS;
D O I：
10.1002/anie.200904634
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH2CI2 in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：899 / 903
页数：5
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