Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood

被引：103

作者：

Prasad, Rashmi B. ^{[1
]}

Hosking, Fay J. ^{[2
]}

Vijayakrishnan, Jayaram ^{[2
]}

Papaemmanuil, Elli ^{[2
]}

Koehler, Rolf ^{[3
]}

Greaves, Mel ^{[4
]}

Sheridan, Eamonn ^{[5
]}

Gast, Andreas ^{[1
]}

Kinsey, Sally E. ^{[6
]}

Lightfoot, Tracy ^{[7
]}

Roman, Eve ^{[7
]}

Taylor, Malcolm ^{[8
]}

Pritchard-Jones, Kathy ^{[9
]}

Stanulla, Martin ^{[10
]}

Schrappe, Martin ^{[10
]}

Bartram, Claus R. ^{[3
]}

Houlston, Richard S. ^{[2
]}

Kumar, Rajiv ^{[1
]}

Hemminki, Kari ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Mol Genet Epidemiol, D-6900 Heidelberg, Germany

[2] Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

[3] Univ Heidelberg, Inst Human Genet, Heidelberg, Germany

[4] Inst Canc Res, Sect Haematooncol, Sutton, Surrey, England

[5] St James Univ Hosp, Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England

[6] St James Univ Hosp, Dept Paediat & Adolescent Oncol & Haematol, Leeds, W Yorkshire, England

[7] Univ York, Epidemiol & Genet Unit, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England

[8] Univ Manchester, St Marys Hosp, Canc Immunogenet Grp, Sch Canc Sci, Manchester M13 0JH, Lancs, England

[9] Inst Canc Res, Sect Paediat Oncol, Sutton, Surrey, England

[10] Univ Kiel, Dept Pediat, D-2300 Kiel, Germany

来源：

BLOOD | 2010年 / 115卷 / 09期

关键词：

IKAROS; GENE; PROTEINS; DELETION; GROWTH; FAMILY;

D O I：

10.1182/blood-2009-09-241513

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent genome-wide association data have implicated genetic variation at 7p12.2 (IKZF1), 10q21.2 (ARIDB5), and 14q11.2 (CEBPE) in the etiology of B-cell childhood acute lymphoblastic leukemia (ALL). To verify and further examine the relationship between these variants and ALL risk, we genotyped 1384 cases of precursor B-cell childhood ALL and 1877 controls from Germany and the United Kingdom. The combined data provided statistically significant support for an association between genotype at each of these loci and ALL risk; odds ratios (OR), 1.69 (P = 7.51 x 10(-22)), 1.80 (P = 5.90 x 10(-28)), and 1.27 (P = 4.90 x 10(-6)), respectively. Furthermore, the risk of ALL increases with an increasing numbers of variant alleles for the 3 loci (ORper-allele = 1.53, 95% confidence interval, 1.44-1.62; P-trend = 3.49 x 10(-42)), consistent with a polygenic model of disease susceptibility. These data provide unambiguous evidence for the role of these variants in defining ALL risk underscoring approximately 64% of cases. (Blood. 2010;115:1765-1767)

引用

页码：1765 / 1767

页数：3

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