Endocytosis of human immunodeficiency virus 1 (HIV-1) in astrocytes: A fiery path to its destination

被引：26

作者：

Chauhan, Ashok ^{[1
]}

Khandkar, Mehrab ^{[1
]}

机构：

[1] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

来源：

MICROBIAL PATHOGENESIS | 2015年 / 78卷

关键词：

HIV-1; brain; persistence; Lysosomotropic drugs; Chloroquine; Proteasome inhibitors; LSP1; Rab; Rev; Tat; CENTRAL-NERVOUS-SYSTEM; LASER CAPTURE MICRODISSECTION; HUMAN FETAL ASTROCYTES; AIDS DEMENTIA COMPLEX; HUMAN GLIAL-CELLS; TYPE-1; INFECTION; BRAIN-TISSUE; DEPENDENT ENDOCYTOSIS; PRODUCTIVE INFECTION; CELLULAR TROPISMS;

D O I：

10.1016/j.micpath.2014.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite successful suppression of peripheral HIV-1 infection by combination antiretroviral therapy, immune activation by residual virus in the brain leads to HIV-associated neurocognitive disorders (HAND). In the brain, several types of cells, including microglia, perivascular macrophage, and astrocytes have been reported to be infected by HIV-1. Astrocytes, the most abundant cells in the brain, maintain homeostasis. The general consensus on HIV-1 infection in astrocytes is that it produces unproductive viral infection. HIV-1 enters astrocytes by pH-dependent endocytosis, leading to degradation of the virus in endosomes, but barely succeeds in infection. Here, we have discussed endocytosis-mediated HIV-1 entry and viral programming in astrocytes. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

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