Endocytosis of human immunodeficiency virus 1 (HIV-1) in astrocytes: A fiery path to its destination

被引：26

作者：

Chauhan, Ashok ^{[1
]}

Khandkar, Mehrab ^{[1
]}

机构：

[1] Univ S Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA

来源：

MICROBIAL PATHOGENESIS | 2015年 / 78卷

关键词：

HIV-1; brain; persistence; Lysosomotropic drugs; Chloroquine; Proteasome inhibitors; LSP1; Rab; Rev; Tat; CENTRAL-NERVOUS-SYSTEM; LASER CAPTURE MICRODISSECTION; HUMAN FETAL ASTROCYTES; AIDS DEMENTIA COMPLEX; HUMAN GLIAL-CELLS; TYPE-1; INFECTION; BRAIN-TISSUE; DEPENDENT ENDOCYTOSIS; PRODUCTIVE INFECTION; CELLULAR TROPISMS;

D O I：

10.1016/j.micpath.2014.11.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite successful suppression of peripheral HIV-1 infection by combination antiretroviral therapy, immune activation by residual virus in the brain leads to HIV-associated neurocognitive disorders (HAND). In the brain, several types of cells, including microglia, perivascular macrophage, and astrocytes have been reported to be infected by HIV-1. Astrocytes, the most abundant cells in the brain, maintain homeostasis. The general consensus on HIV-1 infection in astrocytes is that it produces unproductive viral infection. HIV-1 enters astrocytes by pH-dependent endocytosis, leading to degradation of the virus in endosomes, but barely succeeds in infection. Here, we have discussed endocytosis-mediated HIV-1 entry and viral programming in astrocytes. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

共 96 条

[1] Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/in situ hybridisation technique [J].

An, SF ;

Groves, M ;

Giometto, B ;

Beckett, AAJ ;

Scaravilli, F .

ACTA NEUROPATHOLOGICA, 1999, 98 (05) :481-487

[2] Early entry and widespread cellular involvement of HIV-1 DNA in brains of HIV-1 positive asymptomatic individuals [J].

An, SF ;

Groves, M ;

Gray, F ;

Scaravilli, F .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (11) :1156-1162

[3] Replication of different clones of human immunodeficiency virus type 1 in primary fetal human astroyctes: enhancement of viral gene expression by Nef [J].

Bencheikh, M ;

Bentsman, G ;

Sarkissian, N ;

Canki, M ;

Volsky, DJ .

JOURNAL OF NEUROVIROLOGY, 1999, 5 (02) :115-124

[4] High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells [J].

Blanco, J ;

Bosch, B ;

Fernández-Figueras, MT ;

Barretina, J ;

Clotet, B ;

Esté, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (49) :51305-51314

[5] HIV-1 INFECTION OF THE DEVELOPING NERVOUS-SYSTEM - CENTRAL ROLE OF ASTROCYTES IN PATHOGENESIS [J].

BLUMBERG, BM ;

GELBARD, HA ;

EPSTEIN, LG .

VIRUS RESEARCH, 1994, 32 (02) :253-267

[6]

BLUMENTHAL R, 1987, J BIOL CHEM, V262, P13614

[7] Isolated human astrocytes are not susceptible to infection by M- and T-tropic HIV-1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4 [J].

Boutet, A ;

Salim, H ;

Taoufik, Y ;

Lledo, PM ;

Vincent, JD ;

Delfraissy, JF ;

Tardieu, M .

GLIA, 2001, 34 (03) :165-177

[8] Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis [J].

Brack-Werner, R .

AIDS, 1999, 13 (01) :1-22

[9] INVITRO STUDIES OF HIV-1 EXPRESSION IN THYMOCYTES FROM INFANTS AND CHILDREN [J].

HAYS, EF ;

UITTENBOGAART, CH ;

BREWER, JC ;

VOLLGER, LW ;

ZACK, JA .

AIDS, 1992, 6 (03) :265-272

[10] Transient infection of astrocytes with HIV-1 primary isolates derived from patients with and without AIDS dementia complex [J].

Brengel-Pesce, K ;

Innocenti-Francillard, P ;

Morand, P ;

Chanzy, B ;

Seigneurin, JM .

JOURNAL OF NEUROVIROLOGY, 1997, 3 (06) :449-454

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