The Long Non-Coding RNA HOXC-AS3 Promotes Glioma Progression by Sponging miR-216 to Regulate F11R Expression

被引:4
作者
Li, Yongshuai [1 ]
Peng, Lu [2 ]
Cao, Xianwen [1 ]
Yang, Kun [1 ]
Wang, Zhen [1 ]
Xiao, Yong [1 ]
Xiao, Hong [3 ]
Qian, Chunfa [1 ]
Liu, Hongyi [1 ]
机构
[1] Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Neurosurg, Nanjing, Peoples R China
[2] Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Clin Lab, Nanjing, Peoples R China
[3] Nanjing Med Univ, Affiliated Nanjing Brain Hosp, Dept Neuropsychiat Inst, Nanjing, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
基金
中国国家自然科学基金;
关键词
HOXC-AS3; miR-216; F11R; ceRNA; glioma; JAM-A; ADHESION; CELLS; DIFFERENTIATION; GLIOBLASTOMA; RESISTANCE; CANCER;
D O I
10.3389/fonc.2022.845009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
HOXC cluster antisense RNA 3 (HOXC-AS3) is a long noncoding RNA (lncRNA) that plays a crucial role in various tumors; nevertheless, its role in glioma and its mechanism have not been completely elucidated. In this research, we discovered that HOXC-AS3 was over-expression in glioma cells and tissues and was associated with prognosis. Next, we determined that HOXC-AS3 targeted miR-216 as a sponge and that the F11 receptor (F11R) was the target of miR-216 by online databases analysis, qRT-PCR, and luciferase reporter assay. In addition, the rescue experiments confirmed that HOXC-AS3 regulated the expression of F11R by competitively binding miR-216 and functioning as a competing endogenous RNA (ceRNA). The intracranial glioblastoma mouse model suggested that HOXC-AS3 could promote glioma malignant progression in vivo. In summary, our study shows that the HOXC-AS3/miR-216/F11R axis plays an important role in the malignant progression of glioma, and may provide new ideas for the treatment of glioma.
引用
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页数:12
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