The Na+/H+ Exchanger and pH Regulation in the Heart

被引：38
作者：
Odunewu-Aderibigbe, Ayodeji [1 ]
Fliegel, Larry [1 ]
机构：
[1] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada
来源：
IUBMB LIFE | 2014年 / 66卷 / 10期
关键词：
Na+/H+ exchanger; hypertrophy; pH regulation; ischemia/reperfusion; myocardium; RAT VENTRICULAR MYOCYTES; PROTEIN-KINASE-C; H+ EXCHANGER; MEDIATED REGULATION; HOMOLOGOUS PROTEIN; ELEVATED LEVELS; ISOFORM; NHE1; ACTIVATION; STIMULATION;
D O I：
10.1002/iub.1323
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein ubiquitously expressed in mammalian cells. It is made up of two domains: a 500-amino acid membrane domain that is responsible for transport and removes protons, and a regulatory intracellular cytosolic domain made up of 315 amino acids. NHE1 is the major isoform found in the myocardium where it plays an important role in the regulation of intracellular pH by exchanging one intracellular proton for one extracellular sodium. Although NHE1 normally fulfills this important physiological role, aberrant regulation and overactivation of NHE1 contribute to heart disease, including acute ischemia reperfusion damage and cardiac hypertrophy. This review summarizes past and current knowledge of the role and regulation of NHE1 in the myocardium. (C) 2014 IUBMB Life, 66(10): 679-685, 2014
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收藏
页码：679 / 685
页数：7
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