Sorbicillinoid-Based Metabolites from a Sponge-Derived Fungus Trichoderma saturnisporum

被引：32

作者：

Meng, Junjun ^{[1
,2
]}

Cheng, Wei ^{[1
]}

Heydari, Hajar ^{[3
]}

Wang, Bin ^{[2
]}

Zhu, Kui ^{[4
]}

Konuklugil, Belma ^{[3
]}

Lin, Wenhan ^{[1
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Zhejiang Ocean Univ, Food & Med Coll, Zhoushan 316022, Peoples R China

[3] Ankara Univ, Dept Pharmacoguosy, Fac Pharm, TR-06100 Ankara, Turkey

[4] China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China

来源：

MARINE DRUGS | 2018年 / 16卷 / 07期

基金：

中国国家自然科学基金;

关键词：

marine fungus; Trichoderma saturnisporum; saturnispols A-H; structural elucidation; antibacterial effects; PHIALOCEPHALA SP FL30R; MARINE SPONGE; VERTICILLIUM-INTERTEXTUM; ANTIBACTERIAL ACTIVITY; DICTYONELLA-INCISA; BIOSYNTHESIS; LONGIBRACHIATUM; TRICHODIMEROL; DERIVATIVES; PRECURSOR;

D O I：

10.3390/md16070226

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antibacterial activity assessment and high performance liquid chromatography associated with nuclear magnetic resonance (HPLC/NMR) data revealed that the EtOAc extract of the fermented endophytic fungus Trichoderma saturnisporum DI-IA, obtained from the marine sponge Dictyonella incisa, contained conjugated olefinic metabolites with antibacterial activity. Chemical examination of the fungal strain resulted in the isolation of eight new sorbicillinoid-based compounds, namely saturnispols A-H (1-8). Their structures were determined on the basis of extensive spectroscopic analysis, including the experimental and calculated electronic circular dichroism (ECD) data for the configurational assignments. Saturnispol F exerted significant inhibition against a panel of bacteria strains including vancomycin-resistant enterococci (VRE) with a minimum inhibitory concentrations (MIC) ranging from 1.63 to 12.9 mu g/mL, while saturnispol H showed selective effects against VRE and B. subtilis.

引用

页数：15

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