Visual loss associated with tacrolimus: case report and review of the literature

被引：6

作者：

Kapoor, Kapil G. ^{[1
]}

Mirza, Sarah N. ^{[1
]}

Gonzales, John A. ^{[1
]}

Gibran, Syed K. ^{[1
]}

机构：

[1] Univ Texas Med Branch Galveston, Dept Ophthalmol & Visual Sci, Galveston, TX 77550 USA

来源：

CUTANEOUS AND OCULAR TOXICOLOGY | 2010年 / 29卷 / 02期

关键词：

Tacrolimus; FK506; Prograf; aqueous tear deficiency; dry eyes;

D O I：

10.3109/15569521003662963

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Tacrolimus is an immunosuppressive medication in the class of calcineurin inhibitors that acts by inhibiting T-cell and interleukin-2 activity, and is commonly used after allogeneic organ transplant. We present a patient who used tacrolimus after cadaveric kidney transplant and experienced blurry vision. Ocular examination and patient's course subsequently revealed aqueous tear deficiency as a dose-dependent adverse effect of oral tacrolimus.</.

引用

页码：137 / 139

页数：3

共 11 条

[1] Effect of topical 0.02% tacrolimus aqueous suspension on tear production in dogs with keratoconjunctivitis sicca
Berdoulay, A
English, RV
Nadelstein, B
[J]. VETERINARY OPHTHALMOLOGY, 2005, 8 (04) : 225 - 232
[2] A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation
Brazis, PW
Spivey, JR
Bolling, JP
Steers, JL
[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2000, 129 (04) : 536 - 538
[3] Idiopathic intracranial hypertension following kidney transplantation: A case report and review of the literature
Chamberlain, CE
FitzGibbon, E
Wassermann, EM
Butman, JA
Kettl, D
Hale, D
Kirk, AD
Mannon, RB
[J]. PEDIATRIC TRANSPLANTATION, 2005, 9 (04) : 545 - 550
[4] Mechanisms of clinically relevant drug interactions associated with tacrolimus
Christians, U
Jacobsen, W
Benet, LZ
Lampen, A
[J]. CLINICAL PHARMACOKINETICS, 2002, 41 (11) : 813 - 851
[5] Cytomegalovirus retinitis and FK 506
Ciardella, AP
Barile, G
Langton, K
Chang, S
[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY, 2003, 136 (02) : 386 - 389
[6] Pharmacogenetics of Calcineurin Inhibitors in Renal Transplantation
Coto, Eliecer
Tavira, Beatriz
[J]. TRANSPLANTATION, 2009, 88 (03) : S62 - S67
[7] Adverse drug reactions: definitions, diagnosis, and management
Edwards, IR
Aronson, JK
[J]. LANCET, 2000, 356 (9237) : 1255 - 1259
[8] Fredericks Salim, 2003, Am J Pharmacogenomics, V3, P291, DOI 10.2165/00129785-200303050-00001
[9] PRES (posterior reversible encephalopathy syndrome), a rare complication of tacrolimus therapy
Hodnett P.
Coyle J.
O'Regan K.
Maher M.M.
Fanning N.
[J]. Emergency Radiology, 2009, 16 (6) : 493 - 496
[10] Stephens M.D.B., 1998, DETECTION NEW ADVERS, P32

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