Pan-cancer analysis of the DNA methylation patterns of long non-coding RNA

被引：6
|
作者：
Wang, Shijia [1 ,2 ]
Wang, Rendong [1 ,2 ]
Gao, Fang [3 ]
Huang, Jun [1 ,2 ]
Zhao, Xiaoxiao [1 ,2 ]
Li, Dongguo [1 ,2 ]
机构：
[1] Capital Med Univ, Sch Biomed Engn, 10 You An Men Wai, Beijing 100069, Peoples R China
[2] Capital Med Univ, Beijing Key Lab Fundamental Res Biomech Clin Appl, Beijing 100069, Peoples R China
[3] Binzhou Peoples Hosp, Hlth Management Ctr, Binzhou, Shandong, Peoples R China
来源：
GENOMICS | 2022年 / 114卷 / 04期
关键词：
Pan-cancer; TCGA; DNA methylation; Long non-coding RNA; Co-expression network; CELL-PROLIFERATION; GENE; HYPOMETHYLATION; EPIGENETICS; PROGRESSION; ENRICHMENT; LANDSCAPE; INSIGHTS; LNCRNA;
D O I：
10.1016/j.ygeno.2022.110377
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Long non-coding RNA (lncRNA) regulated by abnormal DNA methylation (ADM-lncRNA) emerges as a biomarker for cancer diagnosis and treatment. This study comprehensively described the methylation patterns of lncRNA in pan-cancer using the cancer data set in The Cancer Genome Atlas (TCGA). Based on the cancer heterogeneity of ADM-lncRNA in pan-cancer, we constructed a co-expression network of pan-cancer ADM-lncRNA (pADMlncRNA) in 10 cancers, highlighting the combined action mode of abnormal DNA methylation, and indicating the internal connection among different cancers. Functional analysis revealed the pan-carcinogenic pathway of pADM-lncRNA and suggested potential factors for cancer heterogeneity and tumor immune microenvironment changes. Survival analysis showed the potential of pADM-lncRNA-mRNA co-expression pair as cancer biomarkers. Revealing the action mode of lncRNA and DNA methylation in cancer may help understand the key molecular mechanisms of cell carcinogenesis.
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页数：11
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