Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection

被引:6
|
作者
Manuela, Kobas [1 ]
Bickle, Graz Myriam [2 ,3 ]
Carmen, Truttmann Anita [3 ]
Eric, Giannoni [3 ]
Pascal, Meylan [4 ,5 ]
Andrea, Asner Sandra [5 ,6 ]
机构
[1] Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland
[2] Lausanne Univ Hosp, Dept Woman Mother Child, Clin Neonatol, Follow Up Unit, Lausanne, Switzerland
[3] Lausanne Univ Hosp, Dept Woman Mother Child, Clin Neonatol, Lausanne, Switzerland
[4] Lausanne Univ Hosp, Dept Labs, Inst Microbiol, Lausanne, Switzerland
[5] Lausanne Univ Hosp, Dept Med, Infect Dis Serv, Lausanne, Switzerland
[6] Lausanne Univ Hosp, Dept Woman Mother Child, Paediat Infect Dis & Vaccinol Unit, Ave Bugnon 46, CH-1011 Lausanne, Switzerland
关键词
congenital CMV infection; sensorineural hearing loss; neurodevelopment; primary infection; nonprimary infection; CENTRAL-NERVOUS-SYSTEM; ORGAN TRANSPLANT PATIENTS; CMV INFECTION; HEARING-LOSS; PREEXISTING IMMUNITY; CHILDREN; MANAGEMENT; INFANTS; SEQUELAE; DISEASE;
D O I
10.4414/smw.2018.14627
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND: Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. AIMS OF THE STUDY: (1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection. METHODS: This was a single-centre, observational, exploratory, retrospective study of newborns diagnosed with cCMV infection at the Lausanne University Hospital between 1999 and 2014. RESULTS: Fifty newborns with cCMV infection were identified; 39 (78%) were symptomatic at birth, of whom 29 (74%) were neurologically symptomatic. Twelve children (24%) presented with subsequent abnormal audiological and/or neurodevelopmental outcomes. Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection. CONCLUSIONS: All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection.
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页数:8
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