Contending with transcriptional arrest during RNAPII transcript elongation

被引：89

作者：

Svejstrup, Jesper Q. ^{[1
]}

机构：

[1] Canc Res UK, London Res Inst, Clare Hall Labs, S Mimms EN6 3LD, Herts, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2007年 / 32卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2007.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies of RNA polymerase II (RNAPII) transcript elongation have revealed an extremely complex biochemical process. Obstacles to transcription, such as nucleosomes and DNA damage, must be overcome constantly, requiring the involvement of numerous accessory factors with diverse functions. Together, these factors ensure that transcript elongation is, overall, a highly efficient reaction. The understanding of the basic biochemical principles and factors underlying transcript elongation by RNAPII has greatly improved over the past few years. In particular, studies of RNAPII ubiquitylation and degradation have provided new insight into how cells handle obstacle-induced transcriptional arrest.

引用

页码：165 / 171

页数：7

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