Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats

被引：69

作者：

Soffritti, M ^{[1
]}

Belpoggi, F ^{[1
]}

Cevolani, D ^{[1
]}

Guarino, M ^{[1
]}

Padovani, M ^{[1
]}

Maltoni, C ^{[1
]}

机构：

[1] European Ramazzini Fdn Oncol & Environm Sci, Ctr Canc Res, Bologna, Italy

来源：

CARCINOGENESIS BIOASSAYS AND PROTECTING PUBLIC HEALTH: COMMEMORATING THE LIFEWORK OF CESARE MALTONI AND COLLEAGUES | 2002年 / 982卷

关键词：

methyl alcohol; ethyl alcohol; carcinogenicity; long-term bioassay; rat;

D O I：

10.1111/j.1749-6632.2002.tb04924.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Methyl alcohol was administered in drinking water supplied ad libitum at doses of 20,000, 5,000, 500, or 0 ppm to groups of male and female Sprague-Dawley rats 8 weeks old at the start of the experiment. Animals were kept under observation until spontaneous death. Ethyl alcohol was administered by ingestion in drinking water at a concentration of 10% or 0% supplied ad libitum to groups of male and female Sprague-Dawley rats; breeders and offspring were included in the experiment. Treatment started at 39 weeks of age (breeders), 7 days before mating, or from embryo life (offspring) and lasted until their spontaneous death. Under tested experimental conditions, methyl alcohol and ethyl alcohol were demonstrated to be carcinogenic for various organs and tissues. They must also be considered multipotential carcinogenic agents. In addition to causing other tumors, ethyl alcohol induced malignant tumors of the oral cavity, tongue, and lips. These sites have been shown to be target organs in man by epidemiologic studies.

引用

页码：46 / 69

页数：24

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