Toll-like receptor activation, vascular endothelial function, and hypertensive disorders of pregnancy

被引：17

作者：

Balasubbramanian, Dakshnapriya ^{[1
]}

Gelston, Catalina A. Lopez ^{[1
]}

Mitchell, Brett M. ^{[1
]}

Chatterjee, Piyali ^{[2
]}

机构：

[1] Texas A&M Univ, Hlth Sci Ctr, Dept Med Physiol, 361A Reynolds Med Bldg, College Stn, TX 77843 USA

[2] Baylor Scott & White Hlth, Dept Internal Med, 702 SW HK Dodgen Loop, Temple, TX 76504 USA

来源：

PHARMACOLOGICAL RESEARCH | 2017年 / 121卷

关键词：

Endothelial dysfunction; Inflammation; Artery; Toll-like receptor; Preeclampsia; Pregnancy; PREECLAMPSIA-LIKE SYMPTOMS; LOW-DOSE-ENDOTOXIN; OXIDATIVE STRESS; BLOOD-PRESSURE; HYPERPOLARIZING FACTOR; VITAMIN-C; INFLAMMATORY CYTOKINES; PREVENTS HYPERTENSION; MITOCHONDRIAL-DNA; STROMAL CELLS;

D O I：

10.1016/j.phrs.2017.04.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aberrant innate immune system activation in the mother contributes greatly to the development of hypertension during pregnancy. Numerous groups have elicited vascular inflammation, endothelial dysfunction, and hypertension in animals during gestation by directly activating Toll-like receptors. Additionally, several experimental therapies that reduce pro-inflammatory immune cells and cytokines restore vascular endothelial function and normalize blood pressure. This review will summarize the research demonstrating that an excessive maternal innate immune response is sufficient to cause vascular inflammation and endothelial dysfunction, which contributes to the development of hypertension during pregnancy. Dampening the vascular inflammation caused by immune responses may reduce the incidence and severity of hypertensive disorders of pregnancy. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：14 / 21

页数：8

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