Synthesis of obeticholic acid, a farnesoid X receptor agonist, and its major metabolites labeled with deuterium

被引：2
|
作者：
Gai, Kuo [1 ]
Huang, Yu [1 ]
Liu, Baomin [1 ]
Zhang, Yinsheng [1 ]
机构：
[1] Chia Tai Tianqing Pharmaceut Grp Co LTD, Jiangsu Key Lab Targeted Antiviral Res, 699-8 Xuanwu Ave,Bldg 9, Nanjing 210023, Jiangsu, Peoples R China
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2018年 / 61卷 / 10期
关键词：
deuterium-labeling; internal standards; metabolites; obeticholic acid;
D O I：
10.1002/jlcr.3643
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Simple and facile methods for the synthesis of deuterium-labeled obeticholic acid and its 2 metabolites, glycine and taurine conjugates of obeticholic acid, are described herein. The 3 deuterated compounds were applicable for use as internal standards in drug development.
引用
收藏
页码：799 / 804
页数：6
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