Synthesis of obeticholic acid, a farnesoid X receptor agonist, and its major metabolites labeled with deuterium

被引：2

作者：

Gai, Kuo ^{[1
]}

Huang, Yu ^{[1
]}

Liu, Baomin ^{[1
]}

Zhang, Yinsheng ^{[1
]}

机构：

[1] Chia Tai Tianqing Pharmaceut Grp Co LTD, Jiangsu Key Lab Targeted Antiviral Res, 699-8 Xuanwu Ave,Bldg 9, Nanjing 210023, Jiangsu, Peoples R China

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2018年 / 61卷 / 10期

关键词：

deuterium-labeling; internal standards; metabolites; obeticholic acid;

D O I：

10.1002/jlcr.3643

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Simple and facile methods for the synthesis of deuterium-labeled obeticholic acid and its 2 metabolites, glycine and taurine conjugates of obeticholic acid, are described herein. The 3 deuterated compounds were applicable for use as internal standards in drug development.

引用

页码：799 / 804

页数：6

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