Dynamic modeling for modulation of ATP concentration at the endothelial surface by viscous shear flow

被引：0

作者：

Qin, Kairong ^{[1
]}

Xu, Zhe ^{[3
]}

Zhang, Hui ^{[3
]}

Xiang, Cheng ^{[2
]}

Sam, Shuzhi ^{[2
]}

Jiang, Zonglai ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Inst Mechanobiol & Med Engn, Shanghai 200240, Peoples R China

[2] Natl Univ Singapore, Dept Elect & Comp Engn, Singapore 117576, Singapore

[3] Fudan Univ, Inst Biomech, Shanghai 200433, Peoples R China

来源：

PROCEEDINGS OF THE 2006 IEEE INTERNATIONAL CONFERENCE ON INTELLIGENT CONTROL | 2006年

基金：

中国国家自然科学基金;

关键词：

shear stress; ATP; mechanotransduction; endothelial cells; dynamic model;

D O I：

暂无

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper, dynamic modeling is investigated for shear stress induced adenosine triphosphate (ATP) release from endothelial cells (ECs). The modulation of ATP concentration at the endothelial surface by viscous shear flow is extensively investigated through numerical analysis based on the release model. The simulation results demonstrate that shear stress induced ATP release, convection and diffusion of ATP, and ATP hydrolysis by ecto-ATPase synergistically determine the ATP concentration against time at endothelium-fluid interface.

引用

页码：267 / +

页数：3

共 22 条

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