Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

被引：14
|
作者：
Chan, L [1 ]
Stefanac, T [1 ]
Turcotte, N [1 ]
Hu, ZH [1 ]
Chen, YM [1 ]
Bédard, J [1 ]
May, S [1 ]
Jin, HL [1 ]
机构：
[1] Biochem Pharma Inc, Laval, PQ H7V 4A7, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期
关键词：
D O I：
10.1016/S0960-894X(00)00265-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1477 / 1480
页数：4
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