Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors

被引：14

作者：

Chan, L ^{[1
]}

Stefanac, T ^{[1
]}

Turcotte, N ^{[1
]}

Hu, ZH ^{[1
]}

Chen, YM ^{[1
]}

Bédard, J ^{[1
]}

May, S ^{[1
]}

Jin, HL ^{[1
]}

机构：

[1] Biochem Pharma Inc, Laval, PQ H7V 4A7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(00)00265-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1477 / 1480

页数：4

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