Early childhood antibiotic utilization for infants discharged from the neonatal intensive care unit

被引：0
|
作者：
Flannery, Dustin D. [1 ,2 ,3 ]
Passarella, Molly [1 ]
Mukhopadhyay, Sagori [1 ,2 ,3 ]
Dhudasia, Miren B. [1 ,3 ]
Gerber, Jeffrey S. [2 ,3 ,4 ]
Lorch, Scott A. [1 ,2 ,3 ]
Hennessy, Sean [5 ]
Puopolo, Karen M. [1 ,2 ,3 ]
机构：
[1] Childrens Hosp Philadelphia, Div Neonatol, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Ctr Pediat Clin Effectiveness, Philadelphia, PA 19104 USA
[4] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA
[5] Univ Penn, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
JOURNAL OF PERINATOLOGY | 2022年 / 42卷 / 07期
基金：
美国医疗保健研究与质量局;
关键词：
PRETERM INFANTS; ASSOCIATION; BIRTH; RATES; INFECTION; CHILDREN; HEALTH; RISK;
D O I：
10.1038/s41372-022-01380-y
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective To determine antibiotic utilization for NICU infants, as compared to non-NICU infants, in the first 3 years after birth hospital discharge. Study design Retrospective observational study using data from Medicaid Analytic Extract including 667 541 newborns discharged from 2007-2011. Associations between NICU admission and antibiotic prescription were assessed using regression models, adjusting for confounders, and stratified by gestational age and birth weight. Results 596 999 infants (89.4%) received >= 1 antibiotic, with a median of 4 prescriptions per 3 person-years (IQR 2-8). Prescribed antibiotics and associated indication were similar between groups. Compared to non-NICU infants (N = 586 227), NICU infants (N = 81 314) received more antibiotic prescriptions (adjusted incidence rate ratio 1.08, 95% confidence interval [CI] (1.08,1.08)). Similar results were observed in all NICU subgroups. Conclusions Antibiotic utilization in early childhood was higher among infants discharged from NICUs compared to non-NICU infants.
引用
收藏
页码：953 / 958
页数：6
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