Brown vs white adipocytes: The PPARγ coregulator story

被引：87

作者：

Koppen, Arjen ^{[1
]}

Kalkhoven, Eric ^{[1
,2
]}

机构：

[1] UMC Utrecht, Dept Metab & Endocrine Dis, NL-3584 EA Utrecht, Netherlands

[2] UMC Utrecht, Dept Paediat Immunol, NL-3584 EA Utrecht, Netherlands

来源：

FEBS LETTERS | 2010年 / 584卷 / 15期

关键词：

Adipogenesis; Transcription; Coactivator; Corepressor; White and brown adipose tissue; PPARgamma; PROLIFERATOR-ACTIVATED-RECEPTOR; NUCLEAR HORMONE-RECEPTORS; RETINOID-X-RECEPTOR; ADIPOSE-TISSUE; TRANSCRIPTIONAL COACTIVATORS; THYROID-HORMONE; BINDING-PROTEIN; GENE-EXPRESSION; ENERGY-BALANCE; CO-REPRESSOR;

D O I：

10.1016/j.febslet.2010.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors. The peroxisome proliferator-activated receptor gamma (PPAR gamma) is considered to be one of the master regulators of adipocyte differentiation. The presence of two functionally distinct types of adipose tissue, white and brown (WAT and BAT), requires an even more complex regulation of adipose tissue development. In this review we will focus on the role of PPAR gamma coregulators in adipogenesis and especially on the role of PPAR gamma coregulators in white and brown adipose tissue. Specificity in coregulator function in WAT and BAT may form an additional level of regulation of adipose tissue development. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：3250 / 3259

页数：10

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