Early seizures: causal events or predisposition to adult epilepsy?

被引:16
作者
Dulac, Olivier
Nabbout, Rima
Plouin, Perrine
Chiron, Catherine
Scheffer, Ingrid E.
机构
[1] Necker Enfants Malad Hosp, AP HP, Dept Neuropediat, Ctr Reference Epilepsies Rares, F-75015 Paris, France
[2] INSERM, U663, Paris, France
[3] Univ Paris 05, Paris, France
[4] Univ Melbourne, Dept Med, Austin Hlth, Melbourne, Vic, Australia
[5] Univ Melbourne, Dept Paediat, Austin Hlth, Melbourne, Vic, Australia
[6] Royal Childrens Hosp, Melbourne, Vic, Australia
关键词
D O I
10.1016/S1474-4422(07)70173-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Past studies have been unable to confirm whether early seizures predispose to epilepsy in adults. Seizures in infancy were Classically thought to cause brain lesions that led to epilepsy in adulthood. However, these infants were not thought to have epilepsy, but acute events that included seizures. Accumulating evidence suggests that early seizures may be associated with, or cause, brain damage; or alternatively, they may be the first expression of a genetic or lesional predisposition to epilepsy. The course of early seizures ranges from transient to life-long, depending on epilepsy syndrome, causes, and treatment. The main factors that determine late or persisting epilepsy after the occurrence of early seizures are protracted seizures, tonic seizures, and involvement of mesial temporal structures. A developmental approach to seizure disorders will aid understanding of epilepsy in adults and improve the design of antiepileptic agents for children and adults.
引用
收藏
页码:643 / 651
页数:9
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