DESIGN OF TEMPERATURE CONTROLLED QUARTZ CRYSTAL MICROBALANCE SYSTEM

被引:14
作者
Kocum, C. [1 ]
Erdamar, A. [1 ]
Ayhan, H. [2 ]
机构
[1] Baskent Univ, Dept Biomed Engn, TR-06490 Ankara, Turkey
[2] Mugla Univ, Fac Sci & Art, Dept Chem, Div Biochem, Kotekli, Mugla, Turkey
关键词
biosensor; differential measurement of QCM; peltier element; quartz crystal microbalance; Sauerbrey equation; temperature controlled QCM; SENSORS; BIOSENSOR; CIRCUITS; TIME;
D O I
10.1080/10739140903427137
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this study, the dual modulated quartz crystal microbalance (QCM) with heating and cooling control has been developed for the quantitative determination of biological molecules, as a biosensor. On the other hand, since, the Sauerbrey formula is misprinted in some publications, the correct form of formula is also discussed. The proposed QCM biosensor has three main parts, which are the oscillator circuit, temperature control circuit, and the differential frequency measurement unit. Colpitts oscillators with the buffer amplifier, microcontroller (PIC16F877) for the temperature control circuit and a peltier element were used for heating and cooling inside the developed system. Differential frequency measurement is a known technique to compensate environmental effects causing instability of crystals. For this reason, one of the crystals is implemented with oscillatory circuits, i.e., the detector; the other one is used as the reference. The designed system was tested between 8 degrees C and 50 degrees C and frequency shift versus temperature is observed at 0.5ppm/degrees C over a given temperature range.
引用
收藏
页码:39 / 51
页数:13
相关论文
共 30 条
  • [1] Canh T.M., 1993, BIOSENSORS
  • [2] Identification of pressure/temperature combinations for optimal pepper (Capsicum annuum) pectin methylesterase activity
    Castro, SM
    Van Loey, A
    Saraiva, JA
    Smout, C
    Hendrickx, M
    [J]. ENZYME AND MICROBIAL TECHNOLOGY, 2006, 38 (06) : 831 - 838
  • [3] A piezoelectric quartz crystal sensor for the determination of coagulation time in plasma and whole blood
    Cheng, TJ
    Chang, HC
    Lin, TM
    [J]. BIOSENSORS & BIOELECTRONICS, 1998, 13 (02) : 147 - 156
  • [4] Interface circuits for quartz-crystal-microbalance sensors
    Eichelbaum, F
    Borngräber, R
    Schröder, J
    Lucklum, R
    Hauptmann, P
    [J]. REVIEW OF SCIENTIFIC INSTRUMENTS, 1999, 70 (05) : 2537 - 2545
  • [5] HONG YK, 2004, SPIE INT C OPT ACT S, P140
  • [6] Design of fuzzy logic controlled thermoelectric renal hypothermia system
    Isik, Hakan
    Sargoglu, Esra
    Guler, Inan
    [J]. INSTRUMENTATION SCIENCE & TECHNOLOGY, 2008, 36 (03) : 310 - 322
  • [7] Koyama M, 2003, P IEEE INT FREQ CONT, P981
  • [8] Quartz crystal microbalance immunosensors for environmental monitoring
    Kurosawa, Shigeru
    Park, Jong-Won
    Aizawa, Hidenobu
    Wakida, Shin-Ichi
    Tao, Hiroaki
    Ishihara, Kazuhiko
    [J]. BIOSENSORS & BIOELECTRONICS, 2006, 22 (04) : 473 - 481
  • [9] Kwon SY, 2006, J KOREAN PHYS SOC, V48, P161
  • [10] Application of a flow type quartz crystal microbalance immunosensor for real time determination of cattle bovine ephemeral fever virus in liquid
    Lee, YG
    Chang, KS
    [J]. TALANTA, 2005, 65 (05) : 1335 - 1342