Two antagonistic gustatory receptor neurons responding to sweet-salty and bitter taste in Drosophila

被引:113
作者
Hiroi, M
Meunier, N
Marion-Poll, F
Tanimura, T
机构
[1] Kyushu Univ, Grad Sch Sci, Dept Biol, Fukuoka 8108560, Japan
[2] INRA Unite Phytopharm & Mediateurs Chim, F-78026 Versailles, France
来源
JOURNAL OF NEUROBIOLOGY | 2004年 / 61卷 / 03期
关键词
taste; sweet; salty; bitter; Drosophila;
D O I
10.1002/neu.20063
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In Drosophila, gustatory receptor neurons (GRNs) occur within hair-like structures called sensilla. Most taste sensilla house four GRNs, which have been named according to their preferred sensitivity to basic stimuli: water (W cell), sugars (S cell), salt at low concentration (L1 cell), and salt at high concentration (L2 cell). Labellar taste sensilla are classified into three types, 1-, s-, and i-type, according to their length and location. Of these, 1- and s-type labellar sensilla possess these four cells, but most i-type sensilla house only two GRNs. In i-type sensilla, we demonstrate here that the first GRN responds to sugar and to low concentrations of salt (10-50 mM NaCl). The second GRN detects a range of bitter compounds, among which strychnine is the most potent; and also to salt at high concentrations (over 400 mM NaCl). Neither type of GRN responds to water. The detection of feeding stimulants in i-type sensilla appears to be performed by one GRN with the combined properties of S + LI cells, while the other GRN detects feeding inhibitors in a similar manner to bitter-sensitive L2 cells on the legs. These sensilla thus house two GRNs having an antagonistic effect on behavior, suggesting that the expression of taste receptors is segregated across them accordingly. (C) 2004 Wiley Periodicals, hic.
引用
收藏
页码:333 / 342
页数:10
相关论文
共 44 条
[1]   A novel family of mammalian taste receptors [J].
Adler, E ;
Hoon, MA ;
Mueller, KL ;
Chandrashekar, J ;
Ryba, NJP ;
Zuker, CS .
CELL, 2000, 100 (06) :693-702
[2]   Sensitivity to chemically diverse phagostimulants in a single gustatory neuron of a polyphagous caterpillar [J].
Bernays, EA ;
Chapman, RF ;
Singer, MS .
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2000, 186 (01) :13-19
[3]  
BLANEY WM, 1975, J EXP BIOL, V62, P555
[4]  
BLANEY WM, 1974, J EXP BIOL, V60, P275
[5]   A putative Drosophila pheromone receptor expressed in male-specific taste neurons is required for efficient courtship [J].
Bray, S ;
Amrein, H .
NEURON, 2003, 39 (06) :1019-1029
[6]   Individual mouse taste cells respond to multiple chemical stimuli [J].
Caicedo, A ;
Kim, KN ;
Roper, SD .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 544 (02) :501-509
[7]   Taste receptor cells that discriminate between bitter stimuli [J].
Caicedo, A ;
Roper, SD .
SCIENCE, 2001, 291 (5508) :1557-1560
[8]   Contact chemoreception infeeding by phytophagous insects [J].
Chapman, RF .
ANNUAL REVIEW OF ENTOMOLOGY, 2003, 48 :455-484
[9]   Candidate taste receptors in Drosophila [J].
Clyne, PJ ;
Warr, CG ;
Carlson, JR .
SCIENCE, 2000, 287 (5459) :1830-1834
[10]   Gustatory neuron types in the periphery: A functional perspective [J].
Contreras, RJ ;
Lundy, RF .
PHYSIOLOGY & BEHAVIOR, 2000, 69 (1-2) :41-52