SIZE-DEPENDENT IMPACTS OF SILVER NANOPARTICLES ON THE LIFESPAN, FERTILITY, GROWTH, AND LOCOMOTION OF CAENORHABDITIS ELEGANS

被引：46

作者：

Contreras, Elizabeth Q. ^{[1
]}

Puppala, Hema L. ^{[1
]}

Escalera, Gabriela ^{[1
]}

Zhong, Weiwei ^{[2
]}

Colvin, Vicki L. ^{[1
]}

机构：

[1] Rice Univ, Dept Chem, Houston, TX USA

[2] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77251 USA

来源：

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY | 2014年 / 33卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Caenorhabditis elegans; Silver nanoparticle; Multigenerational; Toxicity; Escherichia coli; BULK ZNO; TOXICITY;

D O I：

10.1002/etc.2705

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at low (1mg/L Ag), medium (10mg/L Ag), and high concentrations (100mg/L Ag). Over multiple generations, the authors found that the smallest particle, at 2nm, had a notable impact on nematode fertility. In contrast, the largest particle, at 10nm, significantly reduced the lifespan of parent nematodes (P-0) by 28.8% and over the span of 3 generations (F-1-F-3). In addition, a computer vision system automatically measured the adverse effects in body length and motility, which were not size-dependent. Environ Toxicol Chem 2014;33:2716-2723. (c) 2014 SETAC

引用

页码：2716 / 2723

页数：8

共 27 条

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