Protective Effect of Copaifera salikounda Heckel against Paracetamol-Induced Hepatorenal Injury in Rat

被引:0
作者
Aloke, Chinyere [1 ]
Obasi, Nwogo Ajuka [1 ]
Emelike, Chinedum Uche [2 ]
Ogbu, Patience Nkemjika [1 ]
Ufebe, Godswill Odumero [1 ]
Orinya, Onyebuchi Federick [3 ]
Ogbonnia, Egwu Chinedu [1 ]
Onyekwere, Anthony Chinwendu [1 ]
机构
[1] Alex Ekwueme Fed Univ, Fac Basic Med Sci, Dept Med Biochem, Ndufu Alike, Ebonyi State, Nigeria
[2] Alex Ekwueme Fed Univ, Fac Basic Med Sci, Dept Physiol, Ndufu Alike, Ebonyi State, Nigeria
[3] Ebonyi State Univ, Fac Basic Med Sci, Dept Med Biochem, Abakaliki, Ebonyi State, Nigeria
来源
SAINS MALAYSIANA | 2021年 / 50卷 / 04期
关键词
Antioxidant activity; glutathione; hepatoprotective; nephrotoxicity; oxidative stress; paracetamol; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; LIVER; ANTIOXIDANT; FLAVONOIDS; TOXICITY; EXTRACTS; PLASMA; KIDNEY; CHOLESTEROL;
D O I
10.17576/jsm-2021-5004-17
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Drug-induced hepatorenal damage is a significant worldwide clinical challenge. In Nigeria, Copaifera salikounda seed pod ethanol extract (CSSPEE) is used in the treatment of many ailments including liver disorders. This study investigated the protective efficacy of CSSPEE against paracetamol (PCM) induced hepatorenal toxicity. Male albino Wistar rats were assigned at random into five different groups (n = 6). The normal control (Group I) was given normal saline via oral administration while Group II was given 500 mg/kg body weight of PCM via intra-peritoneal administration; Group III was administered 100 mgkg(-1) of silymarin (reference drug) while Groups IV and V were administered 200 and 400 mg kg(-1) of CSSPEE, respectively, per os for seven days prior to administration of PCM. CSSPEE pretreated groups protected PCM-induced hepatorenal damage as reflected by significant diminution (P < 0.05) in liver enzymes activities and levels of malondialdehyde (MDA), total bilirubin (TB), triglycerides (TG) and urea in comparison with group II. Also, CSSPEE pretreatment significantly increased (P < 0.05) the activities of catalase and GSH relative to group II while no significant elevation (P > 0.05) in superoxide dismutase (SOD), glutathione peroxidase (GPx), and high-density lipoprotein (HDL) was observed in comparison to PCM group. CSSPEE also reversed liver and kidney PCM overdose caused histopathological alterations and ameliorated the tissue histology thereby corroborating the results of biochemical findings. CSSPEE produced analogous effects comparable to those produced by silymarin (reference drug). The results indicated that oral administration of CSSPEE conferred a dose-dependent protection against paracetamolinduced oxidative damage to liver and kidney.
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收藏
页码:1065 / 1076
页数:12
相关论文
共 59 条
[11]  
Elekofehinti O. O., 2012, Annals of Biological Research, V3, P3212
[12]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[13]   Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer [J].
Ferreira, Jorge F. S. ;
Luthria, Devanand L. ;
Sasaki, Tomikazu ;
Heyerick, Arne .
MOLECULES, 2010, 15 (05) :3135-3170
[14]  
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[15]   Screening of flavonoids rich fractions of three used for the management of liver diseases [J].
Gupta, Arti ;
Sheth, Navin R. ;
Pandey, Sonia ;
Yadav, Jitendra S. ;
Joshi, Shrikant V. .
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2015, 25 (05) :485-490
[16]   Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats [J].
Guvenc, Mehmet ;
Cellat, Mustafa ;
Gokcek, Ishak ;
Ozkan, Huseyin ;
Arkali, Gozde ;
Yakan, Akin ;
Ozsoy, Sule Yurdagul ;
Aksakal, Mesut .
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2020, 34 (02)
[17]   OXYGEN-TOXICITY, OXYGEN RADICALS, TRANSITION-METALS AND DISEASE [J].
HALLIWELL, B ;
GUTTERIDGE, JMC .
BIOCHEMICAL JOURNAL, 1984, 219 (01) :1-14
[18]   Effects of rosmarinic acid on acetaminophen-induced hepatotoxicity in male Wistar rats [J].
Hasanein, Parisa ;
Sharifi, Maryam .
PHARMACEUTICAL BIOLOGY, 2017, 55 (01) :1809-1816
[19]  
Kandemir FM, 2017, SCI PHARM, V85, DOI 10.3390/scipharm85010004
[20]   Detecting mRNA Predictors of Acetaminophen-Induced Hepatotoxicity in Mouse Blood Using Quantitative Real-Time PCR [J].
Kanno, Syu-ichi ;
Tomizawa, Ayako ;
Yomogida, Shin .
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2016, 39 (03) :440-445