Enantioselective alkynylation of ketones promoted by β-sulfonamide alcohol-titanium complexes

被引：0

作者：

Ming, Ni ^{[1
]}

Yi-Feng, Zhou

Chao, Chen

Jiang-Ke, Xu

Rui, Wang

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Hubei Normal Univ, Dept Biol, Huangshi 435002, Hubei, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 05期

关键词：

ketone; asymmetric; alkynylation; beta-sulfonamide alcohol; catalysis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A readily available beta-sulfonamide alcohol-titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated. simple ketones under very mild conditions. And the corresponding chiral tertiary propargylic alcohols were obtained with enantiomeric excesses of up to 86%, which provided a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.

引用

页码：694 / 697

页数：4

共 49 条

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